肺癌患者外周血中CD4(+)CD25(+)CD127(low)调节性T细胞上PD-1的表达 - Suppr

Expression of PD-1 by CD4(+)CD25(+)CD127(low) Treg cells in the peripheral blood of lung cancer patients.

作者信息

Zhong AnYuan, Pan Xue, Shi MinHua

机构信息

Department of Respiratory Diseases, the Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

出版信息

Onco Targets Ther. 2015 Jul 23;8:1831-3. doi: 10.2147/OTT.S90538. eCollection 2015.

DOI:10.2147/OTT.S90538

PMID:26229490

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4516210/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa2/4516210/5af151e8ec8b/ott-8-1831Fig1.jpg

相似文献

Expression of PD-1 by CD4(+)CD25(+)CD127(low) Treg cells in the peripheral blood of lung cancer patients.肺癌患者外周血中CD4(+)CD25(+)CD127(low)调节性T细胞上PD-1的表达

Onco Targets Ther. 2015 Jul 23;8:1831-3. doi: 10.2147/OTT.S90538. eCollection 2015.

[Analysis of CD4(+)CD25(+)CD127(low/-) Treg cells in mice].[小鼠CD4(+)CD25(+)CD127(low/-)调节性T细胞分析]

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Dec;20(6):1469-73.

[The subpopulation CD4(+); CD25(+); Foxp3(+);/CD127(low/-); regulatory T cells in peripheral blood of HIV-infected patients correlated with disease progression].[HIV感染患者外周血中CD4(+)；CD25(+)；Foxp3(+)；/CD127(低/阴性)调节性T细胞亚群与疾病进展相关]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Nov;28(11):1188-91.

[Changes to CD4(+)CD25(high+)CD127(low) regulatory T cells in peripheral blood from children with bronchiolitis, and its clinical significance].[毛细支气管炎患儿外周血CD4(+)CD25(高+)CD127(低)调节性T细胞的变化及其临床意义]

Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jan;15(1):46-9.

Analysis of the frequencies and functions of CD4CD25CD127, CD4HLA-G, and CD8HLA-G regulatory T cells in pre-eclampsia.分析子痫前期中 CD4CD25CD127+、CD4HLA-G+ 和 CD8HLA-G+ 调节性 T 细胞的频率和功能。

J Reprod Immunol. 2019 Jun;133:43-51. doi: 10.1016/j.jri.2019.06.002. Epub 2019 Jun 21.

Decreased Frequencies of Peripheral Blood CD4+CD25+CD127-Foxp3+ in Patients with Graves' Disease and Graves' Orbitopathy: Enhancing Effect of Insulin Growth Factor-1 on Treg Cells.Graves病和Graves眼病患者外周血CD4+CD25+CD127-Foxp3+细胞频率降低：胰岛素生长因子-1对调节性T细胞的增强作用

Horm Metab Res. 2017 Mar;49(3):185-191. doi: 10.1055/s-0042-122780. Epub 2017 Feb 21.

[Association of PD-1 expression on CD4+ CD25 nt/hi CD127 lo regulatory T cells with disease progression in HIV-1 infected patients].[HIV-1 感染患者中 CD4+ CD25 nt/hi CD127 lo 调节性 T 细胞上 PD-1 表达与疾病进展的关联]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Nov;25(11):1020-2.

Effects of estrogen on CD4(+) CD25(+) regulatory T cell in peripheral blood during pregnancy.孕期外周血 CD4+CD25+调节性 T 细胞中雌激素的作用。

Asian Pac J Trop Med. 2013 Sep;6(9):748-52. doi: 10.1016/S1995-7645(13)60131-5.

Decreased proportions of CD4 + IL17+/CD4 + CD25 + CD127- and CD4 + IL17+/CD4 + CD25 + CD127 - FoxP3+ T cells in children with autoimmune thyroid diseases (.).自身免疫性甲状腺疾病患儿中CD4 + IL17+/CD4 + CD25 + CD127-和CD4 + IL17+/CD4 + CD25 + CD127 - FoxP3+ T细胞比例降低(.)

Autoimmunity. 2016 Aug;49(5):320-8. doi: 10.1080/08916934.2016.1183654. Epub 2016 May 20.

[Analysis of frequency of peripheral blood CD4+; CD25(high);Tregs and CD4+; CD25(low);T cells and expression of PD-1 in SLE and RA patients].[系统性红斑狼疮和类风湿关节炎患者外周血CD4⁺；CD25（高表达）调节性T细胞及CD4⁺；CD25（低表达）T细胞频率与程序性死亡受体1表达的分析]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Jan;27(1):23-5.

引用本文的文献

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist.通过靶向NKG2A递送全新设计的IL-2Rβγ激动剂来调控T细胞和NK细胞用于肿瘤免疫治疗

Drug Deliv. 2025 Dec;32(1):2482195. doi: 10.1080/10717544.2025.2482195. Epub 2025 Apr 1.

The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance.PD-1/PD-L1 通路在伯氏疏螺旋体感染过程中被诱导，抑制 T 细胞的联合浸润，而不影响细菌清除。

PLoS Pathog. 2022 Oct 20;18(10):e1010903. doi: 10.1371/journal.ppat.1010903. eCollection 2022 Oct.

Expression of CD4+CD25+CD127 regulatory T cells and cytokines in peripheral blood of patients with primary liver carcinoma.原发性肝癌患者外周血中 CD4+CD25+CD127 调节性 T 细胞及细胞因子的表达

Int J Med Sci. 2020 Feb 24;17(6):712-719. doi: 10.7150/ijms.44088. eCollection 2020.

The detection and clinical significance of peripheral regulatory CD4CD25CD127 T cells in patients with non-small cell lung cancer.外周血调节性 CD4+CD25+CD127-T 细胞在非小细胞肺癌患者中的检测及临床意义

Clin Transl Oncol. 2019 Oct;21(10):1343-1347. doi: 10.1007/s12094-019-02063-5. Epub 2019 Feb 20.

ImmTAC/Anti-PD-1 antibody combination to enhance killing of cancer cells by reversing regulatory T-cell-mediated immunosuppression.ImmTAC/抗 PD-1 抗体组合通过逆转调节性 T 细胞介导的免疫抑制来增强癌细胞的杀伤作用。

Immunology. 2018 Oct;155(2):238-250. doi: 10.1111/imm.12954. Epub 2018 Jun 14.

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.FOXP3+ Treg 作为促进抗肿瘤免疫的治疗靶点。

Expert Opin Ther Targets. 2018 Apr;22(4):353-363. doi: 10.1080/14728222.2018.1451514. Epub 2018 Apr 10.

The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.癌症患者的外周和肿瘤内免疫细胞格局：肿瘤生物学的替代指标和预后预测工具。

Biomedicines. 2018 Feb 24;6(1):25. doi: 10.3390/biomedicines6010025.

Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-βGal and MVA-MUC1 (TG4010) in a murine tumor model.基于 MVA 的疫苗和 PD-1/PD-L1 阻断抗体序贯给药可显著改善肿瘤生长和存活：在小鼠肿瘤模型中使用 MVA-βGal 和 MVA-MUC1（TG4010）进行的临床前研究。

Hum Vaccin Immunother. 2018 Jan 2;14(1):140-145. doi: 10.1080/21645515.2017.1373921. Epub 2017 Oct 18.

PD-1 and its ligands are important immune checkpoints in cancer.程序性死亡受体1（PD-1）及其配体是癌症中重要的免疫检查点。

Oncotarget. 2017 Jan 10;8(2):2171-2186. doi: 10.18632/oncotarget.13895.

本文引用的文献

Immunologic checkpoint blockade in lung cancer.肺癌中的免疫检查点阻断

Semin Oncol. 2015 Jun;42(3):402-17. doi: 10.1053/j.seminoncol.2015.02.013. Epub 2015 Feb 19.

Regulatory T cells and potential inmmunotherapeutic targets in lung cancer.调节性T细胞与肺癌潜在的免疫治疗靶点

Cancer Metastasis Rev. 2015 Jun;34(2):277-90. doi: 10.1007/s10555-015-9566-0.

The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention.免疫系统在非小细胞肺癌中的作用及治疗干预的潜力。

Transl Lung Cancer Res. 2015 Apr;4(2):177-90. doi: 10.3978/j.issn.2218-6751.2015.01.11.

Neoadjuvant chemo-immunotherapy modifies CD4(+)CD25(+) regulatory T cells (Treg) in non-small cell lung cancer (NSCLC) patients.新辅助化疗免疫治疗改变非小细胞肺癌（NSCLC）患者的 CD4(+)CD25(+)调节性 T 细胞（Treg）。

Lung Cancer. 2014 Jul;85(1):81-7. doi: 10.1016/j.lungcan.2014.04.001. Epub 2014 Apr 13.

Cancer statistics, 2013.癌症统计数据，2013 年。

CA Cancer J Clin. 2013 Jan;63(1):11-30. doi: 10.3322/caac.21166. Epub 2013 Jan 17.

Cancer treatment and survivorship statistics, 2012.癌症治疗与生存统计，2012 年。

CA Cancer J Clin. 2012 Jul-Aug;62(4):220-41. doi: 10.3322/caac.21149. Epub 2012 Jun 14.

Programmed death 1 and cytokine inducible SH2-containing protein dependent expansion of regulatory T cells upon stimulation With Mycobacterium tuberculosis.结核分枝杆菌刺激下程序性死亡 1 和细胞因子诱导的含 SH2 结构域蛋白依赖性调节性 T 细胞扩增。

J Infect Dis. 2011 May 1;203(9):1256-63. doi: 10.1093/infdis/jir011. Epub 2011 Mar 7.

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.程序性细胞死亡-1 信号和调节性 T 细胞协同作用，抵抗过继转移的细胞毒性 T 淋巴细胞在晚期急性髓细胞白血病中的功能。

Blood. 2010 Oct 7;116(14):2484-93. doi: 10.1182/blood-2010-03-275446. Epub 2010 Jun 22.

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.PD-L1 调节诱导性调节 T 细胞的发育、维持和功能。

J Exp Med. 2009 Dec 21;206(13):3015-29. doi: 10.1084/jem.20090847. Epub 2009 Dec 14.

Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.肿瘤表达的 B7-H1 和 B7-DC 与宫颈癌患者 PD-1+T 细胞浸润和生存的关系。

Clin Cancer Res. 2009 Oct 15;15(20):6341-7. doi: 10.1158/1078-0432.CCR-09-1652. Epub 2009 Oct 13.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Expression of PD-1 by CD4(+)CD25(+)CD127(low) Treg cells in the peripheral blood of lung cancer patients.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献