统计分析中的常见陷阱：临床意义与统计学意义
Common pitfalls in statistical analysis: Clinical versus statistical significance.
作者信息
Ranganathan Priya, Pramesh C S, Buyse Marc
机构信息
Department of Anaesthesiology, Division of Thoracic Surgery, Tata Memorial Centre, Parel, Mumbai, Maharashtra, India.
Department of Surgical Oncology, Division of Thoracic Surgery, Tata Memorial Centre, Parel, Mumbai, Maharashtra, India.
出版信息
Perspect Clin Res. 2015 Jul-Sep;6(3):169-70. doi: 10.4103/2229-3485.159943.
Abstract
In clinical research, study results, which are statistically significant are often interpreted as being clinically important. While statistical significance indicates the reliability of the study results, clinical significance reflects its impact on clinical practice. The third article in this series exploring pitfalls in statistical analysis clarifies the importance of differentiating between statistical significance and clinical significance.
摘要
在临床研究中，具有统计学显著性的研究结果常常被解读为具有临床重要性。虽然统计学显著性表明了研究结果的可靠性，但临床显著性反映的是其对临床实践的影响。本系列探讨统计分析陷阱的第三篇文章阐明了区分统计学显著性和临床显著性的重要性。
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本文引用的文献
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2
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3
CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials.CONSORT 2010 声明：平行组随机试验报告的更新指南。
Ann Intern Med. 2010 Jun 1;152(11):726-32. doi: 10.7326/0003-4819-152-11-201006010-00232. Epub 2010 Mar 24.
4
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.厄洛替尼联合吉西他滨与吉西他滨单药治疗晚期胰腺癌患者的比较：加拿大国家癌症研究所临床试验组的一项III期试验
J Clin Oncol. 2007 May 20;25(15):1960-6. doi: 10.1200/JCO.2006.07.9525. Epub 2007 Apr 23.
5
The statistical versus clinical significance debate.统计学意义与临床意义之争
Image J Nurs Sch. 1993 Spring;25(1):57-62. doi: 10.1111/j.1547-5069.1993.tb00754.x.
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