Dobrzyńska Małgorzata M, Gajowik Aneta, Radzikowska Joanna, Tyrkiel Ewa J, Jankowska-Steifer Ewa A
National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
Mutat Res Genet Toxicol Environ Mutagen. 2015 Aug;789-790:36-45. doi: 10.1016/j.mrgentox.2015.06.015. Epub 2015 Jun 30.
We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation. Males were exposed for 8 weeks to BPA, X-rays or both agents, and mated to unexposed females. Pre- and postnatal development of the offspring of exposed males was examined. Both BPA alone and the combined exposure slightly affected postnatal development. Combined exposure induced two-fold higher postnatal mortality than BPA the alone, whereas BPA exposure caused reduced body weight and diminished sperm quality in F1 generation.
我们研究了在受孕前让小鼠单独或联合接受X射线照射的同时接触双酚A（BPA）后，可遗传变化通过精子进行可能传播的情况。雄性小鼠接受8周的BPA、X射线或两种因素联合照射，然后与未接触过这些因素的雌性小鼠交配。对受照射雄性小鼠后代的出生前和出生后发育情况进行了检查。单独使用BPA以及联合照射均对出生后发育有轻微影响。联合照射导致的出生后死亡率比单独使用BPA时高出两倍，而BPA暴露导致F1代体重减轻和精子质量下降。
