Khan Deena, Ansar Ahmed S
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, VA, USA.
Front Genet. 2015 Jul 14;6:236. doi: 10.3389/fgene.2015.00236. eCollection 2015.
In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in infections, overproduction of IL-17 promotes inflammation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Regulating IL-17 levels or action by using IL-17-blocking antibodies or IL-17R antagonist has shown to attenuate experimental autoimmune diseases. It is now known that in addition to IL-17-specific transcription factor, RORγt, several other transcription factors and select microRNAs (miRNA) regulate IL-17. Given that miRNAs are dysregulated in autoimmune diseases, a better understanding of transcriptional factors and miRNA regulation of IL-17 expression and function will be essential for devising potential new therapies. In this review, we will overview IL-17 induction and function in relation to autoimmune diseases. In addition, current findings on transcriptional regulation of IL-17 induction and plausible interplay between IL-17 and miRNA in autoimmune diseases are highlighted.
近年来，促炎细胞因子白细胞介素-17A（IL-17）在炎症和自身免疫性疾病中的作用已被证实，受到了研究人员和临床医生的广泛关注。IL-17可动员、募集并激活不同细胞，从而加剧炎症。尽管IL-17在感染中具有保护作用，但在多发性硬化症、类风湿性关节炎、银屑病等自身免疫性疾病中，IL-17的过量产生会促进炎症反应。使用IL-17阻断抗体或IL-17R拮抗剂调节IL-17水平或作用已显示可减轻实验性自身免疫性疾病。现在已知，除了IL-17特异性转录因子RORγt外，其他几种转录因子和特定的微小RNA（miRNA）也可调节IL-17。鉴于miRNA在自身免疫性疾病中失调，更好地了解转录因子和miRNA对IL-17表达及功能的调节对于设计潜在的新疗法至关重要。在本综述中，我们将概述IL-17与自身免疫性疾病相关的诱导及功能。此外，还将重点介绍目前关于IL-17诱导的转录调控以及自身免疫性疾病中IL-17与miRNA之间可能的相互作用的研究结果。
