热带及与旅行相关的诺如病毒：当前概念
Tropical and travel-associated norovirus: current concepts.
作者信息
Ballard Sarah-Blythe, Saito Mayuko, Mirelman Andrew J, Bern Caryn, Gilman Robert H
机构信息
aDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA bDepartment of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan cAsociación Benéfica PRISMA, Lima, Peru dCentre for Health Economics, University of York, Heslington, UK eDepartment of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine, San Francisco, California, USA fLaboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru.
出版信息
Curr Opin Infect Dis. 2015 Oct;28(5):408-16. doi: 10.1097/QCO.0000000000000197.
PURPOSE OF REVIEW
We highlight recent advances relevant to understanding norovirus infections in the tropics, both in populations living in developing settings and travelers to these regions.
RECENT FINDINGS
Because of the decrease in diarrheal disease associated with the global rollout of vaccines against rotavirus, norovirus is emerging as the predominant cause of diarrhea morbidity among children in the tropics, and evidence suggests that it contributes to adult disease in endemic populations and travelers. In addition to identifying potential target populations for preventive measures, we provide an update on norovirus vaccine development and concepts related to their implementation in low-income and middle-income countries.
SUMMARY
These current concepts related to norovirus-attributable disease burden, clinical significance, and economic impact can potentially be applied to tailoring efforts to prevent and mitigate the effects of this important enteropathogen.
综述目的
我们重点介绍了与了解热带地区诺如病毒感染相关的最新进展，这些进展涉及生活在发展中环境的人群以及前往这些地区的旅行者。
最新发现
由于全球推广轮状病毒疫苗后腹泻病有所减少，诺如病毒正成为热带地区儿童腹泻发病的主要原因，且有证据表明它在流行地区的成人疾病以及旅行者中也有发病。除了确定预防措施的潜在目标人群外，我们还提供了诺如病毒疫苗研发的最新情况以及在低收入和中等收入国家实施相关疫苗的概念。
总结
这些与诺如病毒所致疾病负担、临床意义和经济影响相关的当前概念，有可能应用于调整预防和减轻这种重要肠道病原体影响的工作。
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