Panther David J, Jacob Sharon E
Department of Dermatology, Loma Linda University, 11370 Anderson St. Ste. 2400, Loma Linda, CA 92354, USA.
J Clin Med. 2015 May 18;4(5):970-8. doi: 10.3390/jcm4050970.
Atopic dermatitis is a form of dermatitis commonly seen in children and adults. Its pathophysiology is complex and is centered on the barrier function of the epidermis. An important aspect of the skin's barrier is pH, which in turn affects a number of parameters such as the skin flora, protease function, and mediators of inflammation and pruritus. Normal pH for non-neonatal skin is acidic and ranges from 4 to 6. Skin pH in atopic dermatitis patients is often increased into the neutral to basic range, and the resulting cascade of changes contributes to the phenotype of atopic dermatitis. Therefore, the maintenance of normal skin pH remains an important topic in understanding and treating atopic dermatitis. This article will review skin pH and its impact on normal barrier function, pathological pH changes in atopic dermatitis, and the therapeutic considerations related to restoring and maintaining pH balance.
特应性皮炎是一种常见于儿童和成人的皮炎形式。其病理生理学较为复杂，以表皮的屏障功能为核心。皮肤屏障的一个重要方面是pH值，它反过来又会影响许多参数，如皮肤菌群、蛋白酶功能以及炎症和瘙痒介质。非新生儿皮肤的正常pH值呈酸性，范围在4至6之间。特应性皮炎患者的皮肤pH值通常会升高至中性至碱性范围，由此产生的一系列变化促成了特应性皮炎的表型。因此，维持正常皮肤pH值仍然是理解和治疗特应性皮炎的一个重要课题。本文将综述皮肤pH值及其对正常屏障功能的影响、特应性皮炎中的病理性pH值变化以及与恢复和维持pH值平衡相关的治疗考量。
