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两名回国的加拿大旅行者接受蒿甲醚肠外治疗严重疟疾后的延迟性溶血

Delayed Hemolysis After Parenteral Artesunate Therapy for Severe Malaria in Two Returning Canadian Travelers.

作者信息

Charles Marthe, Patterson Jeffery M, Asadi Leyla, Houston Stan

机构信息

Department of Medical Microbiology, University of Alberta, Alberta, Canada; Department of Medicine, Division of Hematology, University of Alberta, Alberta, Canada; Department of Medicine, Division of Infectious Diseases, University of Alberta, Alberta, Canada.

Department of Medical Microbiology, University of Alberta, Alberta, Canada; Department of Medicine, Division of Hematology, University of Alberta, Alberta, Canada; Department of Medicine, Division of Infectious Diseases, University of Alberta, Alberta, Canada

出版信息

Am J Trop Med Hyg. 2015 Oct;93(4):819-21. doi: 10.4269/ajtmh.15-0268. Epub 2015 Aug 3.

Abstract

Delayed hemolysis after parenteral artesunate has been described in Europe and Asia, but until recently had not been reported in patients receiving the artesunate product used in the United States and Canada. We report two cases of severe delayed hemolysis after the treatment with intravenous artesunate in Canada.

摘要

欧洲和亚洲曾报道过接受青蒿琥酯注射后出现延迟性溶血的情况,但直到最近,在美国和加拿大使用的青蒿琥酯产品治疗的患者中尚未有相关报告。我们报告了加拿大两例静脉注射青蒿琥酯治疗后出现严重延迟性溶血的病例。

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本文引用的文献

1
Severe delayed hemolysis associated with regulated parenteral antimalarial drug.
Emerg Infect Dis. 2015 Jan;21(1):164-6. doi: 10.3201/eid2101.140147.
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Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins.
Blood. 2014 Jul 10;124(2):167-75. doi: 10.1182/blood-2014-02-555953. Epub 2014 May 23.

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