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《2017年疟疾:临床文献与管理最新进展》

Malaria 2017: Update on the Clinical Literature and Management.

作者信息

Daily Johanna P

机构信息

Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY, 10461, USA.

出版信息

Curr Infect Dis Rep. 2017 Aug;19(8):28. doi: 10.1007/s11908-017-0583-8.

DOI:10.1007/s11908-017-0583-8
PMID:28634831
Abstract

PURPOSE OF REVIEW

Malaria is a prevalent disease in travelers to and residents of malaria-endemic regions. Health care workers in both endemic and non-endemic settings should be familiar with the latest evidence for the diagnosis, management and prevention of malaria. This article will discuss the recent malaria epidemiologic and medical literature to review the progress, challenges, and optimal management of malaria.

RECENT FINDINGS

There has been a marked decrease in malaria-related global morbidity and mortality secondary to malaria control programs over the last few decades. This exciting progress is tempered by continued levels of high transmission in some regions, the emergence of artemisinin-resistant Plasmodium falciparum malaria in Southeast Asia, and the lack of a highly protective malaria vaccine. In the United States (US), the number of travelers returning with malaria infection has increased over the past few decades. Thus, US health care workers need to maintain expertise in the diagnosis and treatment of this infection. The best practices for treatment and prevention of malaria need to be continually updated based on emerging data. Here, we present an update on the recent literature on malaria epidemiology, drug resistance, severe disease, and prevention strategies.

摘要

综述目的

疟疾在前往疟疾流行地区的旅行者和当地居民中是一种常见疾病。地方病流行地区和非流行地区的医护人员都应熟悉疟疾诊断、管理和预防的最新证据。本文将讨论近期疟疾流行病学和医学文献,以回顾疟疾的进展、挑战和最佳管理方法。

最新发现

在过去几十年中,由于疟疾控制项目,全球疟疾相关的发病率和死亡率显著下降。在一些地区持续的高传播水平、东南亚出现对青蒿素耐药的恶性疟原虫疟疾以及缺乏高度保护性的疟疾疫苗,使这一令人振奋的进展受到影响。在美国,过去几十年中感染疟疾回国的旅行者人数有所增加。因此,美国医护人员需要保持对这种感染的诊断和治疗方面的专业知识。需要根据新出现的数据不断更新疟疾治疗和预防的最佳做法。在此,我们介绍近期关于疟疾流行病学、耐药性、重症疾病和预防策略的文献更新情况。

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J Clin Microbiol. 2017 Jul;55(7):2009-2017. doi: 10.1128/JCM.02562-16. Epub 2017 Apr 12.
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Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled Trial.双氢青蒿素加哌喹大规模药物治疗对赞比亚南部省份疟疾的短期影响:一项整群随机对照试验
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Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised Trial.
双吲哚环丁烯二酮的合成及抗疟活性。
Molecules. 2021 Aug 5;26(16):4739. doi: 10.3390/molecules26164739.
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4-Arylthieno[2,3-]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents.4-芳基噻吩并[2,3-b]吡啶-2-甲酰胺类是一类新型的抗疟药物。
Molecules. 2020 Jul 13;25(14):3187. doi: 10.3390/molecules25143187.
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Level of circulating steroid hormones in malaria and cutaneous leishmaniasis: a case control study.疟疾和皮肤利什曼病患者循环类固醇激素水平:一项病例对照研究。
J Parasit Dis. 2019 Mar;43(1):54-58. doi: 10.1007/s12639-018-1055-2. Epub 2018 Nov 20.
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Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines.一系列抗疟噻吩并[2,3-b]吡啶的构效关系。
Malar J. 2019 Mar 21;18(1):89. doi: 10.1186/s12936-019-2725-y.
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EMBO J. 2018 Apr 3;37(7). doi: 10.15252/embj.201798047. Epub 2018 Mar 8.
塞内加尔10岁以下儿童季节性疟疾化学预防的效果:一项阶梯式楔形整群随机试验
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