Pappachan Joseph M, Viswanath Ananth K
Joseph M Pappachan, Ananth K Viswanath, Department of Endocrinology and Diabetes, New Cross Hospital, the Royal Wolverhampton Hospital NHS Trust, Wolverhampton WV10 0QP, United Kingdom.
World J Diabetes. 2015 Jul 25;6(8):990-8. doi: 10.4239/wjd.v6.i8.990.
Obesity and type 2 diabetes mellitus (T2DM) are major public health issues globally over the past few decades. Despite dietary interventions, lifestyle modifications and the availability of several pharmaceutical agents, management of T2DM with obesity is a major challenge to clinicians. Metabolic surgery is emerging as a promising treatment option for the management of T2DM in the obese population in recent years. Several observational studies and a few randomised controlled trials have shown clear benefits of various bariatric procedures in obese individuals in terms of improvement or remission of T2DM and multiple other health benefits such as improvement of hypertension, obstructive sleep apnoea, osteoarthritis and non-alcoholic fatty liver disease. Uncertainties about the long-term implications of metabolic surgery such as relapse of T2DM after initial remission, nutritional and psychosocial complications and the optimal body mass index for different ethnic groups exist. The article discusses the major paradigm shift in recent years in the management of T2DM after the introduction of metabolic surgery.
在过去几十年里,肥胖和2型糖尿病(T2DM)一直是全球主要的公共卫生问题。尽管有饮食干预、生活方式改变以及多种药物可用,但对伴有肥胖的T2DM进行管理仍是临床医生面临的重大挑战。近年来,代谢手术正成为肥胖人群T2DM管理中一种有前景的治疗选择。多项观察性研究和一些随机对照试验表明,各种减肥手术对肥胖个体有明显益处,可改善或缓解T2DM,并带来多种其他健康益处,如改善高血压、阻塞性睡眠呼吸暂停、骨关节炎和非酒精性脂肪性肝病。代谢手术的长期影响存在不确定性,如T2DM初始缓解后复发、营养和心理社会并发症以及不同种族的最佳体重指数等问题。本文讨论了近年来引入代谢手术后T2DM管理方面的主要范式转变。