铑（III）催化吲哚通过C-H活化的三氟甲硫基化反应

Rh(III)-Catalyzed Trifluoromethylthiolation of Indoles via C-H Activation.

作者信息

Wang Qiang, Xie Fang, Li Xingwei

机构信息

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

出版信息

J Org Chem. 2015 Aug 21;80(16):8361-6. doi: 10.1021/acs.joc.5b00940. Epub 2015 Aug 10.

DOI:10.1021/acs.joc.5b00940

PMID:26241737

Abstract

Cp*Rh(III) complexes have been applied as efficient catalysts for the C-H activation and trifluoromethylthiolation of indoles functionalized with a heterocycle. With N-trifluoromethylthiosaccharin being an electrophilic SCF3 reagent, this C-S coupling occurred selectively at the 2-position with good functional group tolerance.

摘要

Cp*Rh(III)配合物已被用作高效催化剂，用于对带有杂环的吲哚进行C-H活化和三氟甲硫基化反应。使用N-三氟甲硫基糖精作为亲电SCF3试剂，这种C-S偶联反应选择性地发生在2-位，且具有良好的官能团耐受性。