Ayuso Maria I, Chioua Mourad, Martínez-Alonso Emma, Soriano Elena, Montaner Joan, Masjuán Jaime, Hadjipavlou-Litina Dimitra J, Marco-Contelles José, Alcázar Alberto
Department of Investigation, Hospital Ramón y Cajal, IRYCIS , Madrid 28034, Spain.
Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC) , Juan de la Cierva 3, Madrid 29006, Spain.
J Med Chem. 2015 Aug 27;58(16):6704-9. doi: 10.1021/acs.jmedchem.5b00755. Epub 2015 Aug 13.
This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.
本研究将胆固醇硝酮2描述为一种抗氧化剂和针对缺血性损伤的神经保护剂。使用体外和体内实验性缺血模型评估神经保护作用。该化合物显著提高了细胞活力，在缺血再灌注后诱导了神经保护作用，并降低了治疗动物的神经功能缺损评分，为作为中风治疗的潜在药物的下一步临床前研究提供了支持。
