Xu Miyang, Qiu Chenhao, Zhang Dongxue, Tang Xuehua, Zhang Jiangfeng, Wang Yipeng, Zhu Yichen, Wang Yongli, Li Xiongfeng
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China.
Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, China.
Sci Rep. 2025 May 4;15(1):15574. doi: 10.1038/s41598-025-00251-8.
Numerous clinical studies indicate that reproductive factors and physical performance levels are significant predictors of bone mineral density (BMD) in postmenopausal women. However, research on the relationship between these factors and body composition remains limited, and the mediating role of body composition in the impact of these factors on BMD remains unclear. This cross-sectional study aims to explore the correlation between reproductive factors, physical performance levels, BMD, and body composition in postmenopausal women, and to further investigate the mediating role of body composition in these relationships. This study enrolled 102 postmenopausal women meeting predetermined criteria from the osteoporosis outpatient clinic of Huzhou Central Hospital, China. Data were collected through surveys, assessments of physical performance function, and dual-energy X-ray absorptiometry (DXA) measurements. Correlation analysis and multiple linear regression analysis were used to determine the relationships among factors. Mediation analysis was conducted to explore the mediating role of body composition, followed by logistic regression analysis to investigate risk factors for osteoporosis. Gynoid Lean Muscle Mass (GLM) emerged as an independent predictive factor for BMD of spine, hip, and total body, and a protective factor against osteoporosis. Hand grip and 6-meter gait speed were positively correlated with BMD at these skeletal sites and GLM, also serving as protective factors against osteoporosis. Conversely, menarche age and Time taken for 5 sit-ups exhibited negative correlations with BMD and GLM, concurrently representing risk factors for osteoporosis. GLM mediated the relationship between menarche age, hand grip, and hip BMD. Prolonged reproductive periods and enhanced physical performance appear beneficial in mitigating Lean Mass loss, particularly GLM, in postmenopausal women, thereby protecting BMD and effectively preventing osteoporosis.
众多临床研究表明，生殖因素和身体机能水平是绝经后女性骨密度（BMD）的重要预测指标。然而，关于这些因素与身体成分之间关系的研究仍然有限，并且身体成分在这些因素对骨密度影响中的中介作用仍不明确。这项横断面研究旨在探讨绝经后女性生殖因素、身体机能水平、骨密度和身体成分之间的相关性，并进一步研究身体成分在这些关系中的中介作用。本研究纳入了来自中国湖州市中心医院骨质疏松门诊符合预定标准的102名绝经后女性。通过调查、身体机能功能评估和双能X线吸收法（DXA）测量收集数据。采用相关性分析和多元线性回归分析来确定各因素之间的关系。进行中介分析以探讨身体成分的中介作用，随后进行逻辑回归分析以研究骨质疏松的危险因素。臀肌瘦肌肉量（GLM）成为脊柱、髋部和全身骨密度的独立预测因素，也是预防骨质疏松的保护因素。握力和6米步速与这些骨骼部位的骨密度和GLM呈正相关，同样作为预防骨质疏松的保护因素。相反，初潮年龄和5次仰卧起坐所用时间与骨密度和GLM呈负相关，同时也是骨质疏松的危险因素。GLM介导了初潮年龄、握力和髋部骨密度之间的关系。延长生育期和提高身体机能水平似乎有利于减轻绝经后女性瘦体重的流失，尤其是GLM的流失，从而保护骨密度并有效预防骨质疏松。
