中国人群中pre-miR-218 rs11134527多态性与癌症风险的定量评估。

Quantitative assessment of pre-miR-218 rs11134527 polymorphism and cancer risk in Chinese population.

作者信息

Zhao Hongyu, Wang Rui

机构信息

Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.

Nanjing Kingmed Clinical Laboratory Co., Ltd, Nanjing, People's Republic of China.

出版信息

Onco Targets Ther. 2015 Jul 24;8:1859-62. doi: 10.2147/OTT.S88480. eCollection 2015.

DOI:10.2147/OTT.S88480

PMID:26244022

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4521665/

Abstract

BACKGROUND

Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.

METHODS

To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS

Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88-0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79-0.97; GG versus AA, OR =0.85, 95% CI: 0.76-0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versus A, OR =0.90, 95% CI: 0.83-0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68-0.94; GG versus AA, OR =0.79, 95% CI: 0.66-0.94).

CONCLUSION

These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies.

摘要

背景

已有多项研究评估了前体微小核糖核酸-218（pre-miR-218）rs11134527基因多态性与中国人群癌症风险之间的关联。然而，结果仍存在争议。

方法

为了更精确、更全面地评估二者之间的关系，纳入了六项针对中国人群的研究，采用优势比（OR）及95%置信区间（CI）对pre-miR-218 rs11134527基因多态性进行荟萃分析。

结果

pre-miR-218 rs11134527基因多态性与癌症风险相关（G与A相比，OR = 0.93，95% CI：0.88 - 0.98；GG与AG + AA相比，OR = 0.88，95% CI：0.79 - 0.97；GG与AA相比，OR = 0.85，95% CI：0.76 - 0.96）。在按癌症类型进行的分层分析中，pre-miR-218 rs11134527基因多态性仅与宫颈癌风险相关（G与A相比，OR = 0.90，95% CI：0.83 - 0.98；GG与AG + AA相比，OR = 0.80，95% CI：0.68 - 0.94；GG与AA相比，OR = 0.79，95% CI：