Jiang Lin, Wang Chaofu, Sun Canlin, Xu Yumin, Ding Zhongqi, Zhang Xueling, Huang Junxing, Yu Hong
Department of Anesthesiology, Taizhou People's Hospital Taizhou, Jiangsu, China.
Department of Pathology, Shanghai Cancer Center Fudan University Shanghai, China.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6206-12. eCollection 2014.
MicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes. The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma (ESCC). Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. Pri-mir-218 rs11134527 was significantly associated with a decreased risk of ESCC under codominant, recessive and additive models. Although there was a significant association between rs11134527 and better survival of ESCC patients under codominant, recessive and additive models, the association disappeared after adjustment for TNM and LNM. However, further stratified analysis revealed that the association remained significant in patients with TNM stages I and II or non-LNM. Our data suggest that pri-miR-218 rs11134527 may contribute to the genetic susceptibility and prognosis for ESCC in Chinese Han population.
微小RNA-218（miR-218）通过调控靶基因的表达在多种癌症中发挥肿瘤抑制作用。本研究旨在探讨miR-218 LAMB3通路中的多态性是否与食管鳞状细胞癌（ESCC）的风险及预后相关。对ESCC患者和745名对照者进行了前体miR-218 rs11134527和LAMB3 rs2566基因分型，以评估它们与癌症风险和总生存期的关联。在前体miR-218 rs11134527的共显性、隐性和加性模型下，其与ESCC风险降低显著相关。虽然在共显性、隐性和加性模型下，rs11134527与ESCC患者更好的生存期存在显著关联，但在调整TNM和LNM后该关联消失。然而，进一步的分层分析显示，在TNM I期和II期患者或无淋巴结转移（LNM）患者中该关联仍然显著。我们的数据表明，前体miR-218 rs11134527可能与中国汉族人群ESCC的遗传易感性和预后有关。
