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Tumour Biol. 2013 Jun;34(3):1919-23. doi: 10.1007/s13277-013-0736-9. Epub 2013 Mar 17.
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A pri-miR-218 variant and risk of cervical carcinoma in Chinese women.miR-218 前体变体与中国女性宫颈癌风险。
BMC Cancer. 2013 Jan 15;13:19. doi: 10.1186/1471-2407-13-19.
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A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer.miR-34b/c 启动子区域的遗传变异与结直肠癌风险降低相关。
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A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population.一个 miRNA-27a 前体的基因变异与中国人群的肾细胞癌风险降低有关。
PLoS One. 2012;7(10):e46566. doi: 10.1371/journal.pone.0046566. Epub 2012 Oct 30.
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miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.miR-124 通过下调 SPHK1 抑制胃癌细胞增殖。
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Neurosci Lett. 2012 Apr 25;515(1):1-6. doi: 10.1016/j.neulet.2012.02.061. Epub 2012 Mar 10.
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Epigenetic inactivation of the miR-124-1 in haematological malignancies.血液系统恶性肿瘤中 miR-124-1 的表观遗传失活。
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pri-miR-124 rs531564 和 pri-miR-34b/c rs4938723 多态性与中国人群食管鳞癌风险降低相关。

Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

机构信息

Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.

Clinical laboratory, Huadong Sanatorium, Dajishan, Meiyuan Garden, Wuxi, Jiangsu, China.

出版信息

PLoS One. 2014 Jun 19;9(6):e100055. doi: 10.1371/journal.pone.0100055. eCollection 2014.

DOI:10.1371/journal.pone.0100055
PMID:24945256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4063769/
Abstract

UNLABELLED

MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS.

TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.

摘要

未加标签

microRNAs 是一类新的小非编码 RNA，有时作为肿瘤抑制因子或癌基因发挥作用。已经报道 microRNAs 的表达异常和结构改变与肿瘤发生和癌症发展有关。最近，rs531564/pri-miR-124-1、rs4938723/pri-miR-34b/c、rs7372209/pri-miR-26a-1、rs895819/pre-miR-27a 和 rs11134527/pri-miR-218 被报道与各种癌症的风险相关。为了评估这些 SNP 与食管鳞状细胞癌（ESCC）风险的关系，我们进行了一项病例对照研究，共纳入 1109 例 ESCC 患者和 1275 例对照，以研究这些 pri/pre-miRNA 多态性与 ESCC 易感性的潜在关联。结果显示，两个 SNP 与 ESCC 的发病风险显著相关。我们发现，与 CC/CG 基因型相比，pri-miR-124-1 rs531564 的 GG 基因型与 ESCC 显著降低的风险相关（p = 0.005；OR = 0.61，95%CI = 0.43-0.86）。此外，与 TT/TC 基因型相比，pri-miR-34b/c rs4938723 的 CC 基因型与 ESCC 显著降低的风险相关（CC VS. TT/TC：p = 0.007，OR = 0.82，95%CI = 0.71-0.95）。本研究首次提供了证据表明 pri-miR-124-1 rs531564 和 pri-miR-34 rs4938723 与中国人群 ESCC 的发病风险相关。