载脂蛋白A5基因启动子区域T-1131C多态性（rs12286037）与生活方式改变对日本人群血浆甘油三酯水平的相互作用。
The interaction of Apolipoprotein A5 gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese.
作者信息
Yamasaki Masayuki, Mutombo Paulin Beya Wa Bitadi, Iwamoto Mamiko, Nogi Akiko, Hashimoto Michio, Nabika Toru, Shiwaku Kuninori
机构信息
Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
Department of Nutrition, School of Public Health, Faculty of Medicine, University of Kinshasa, B.P. 127 Kinshasa XI, Democratic Republic of Congo.
出版信息
Nutr Res Pract. 2015 Aug;9(4):379-84. doi: 10.4162/nrp.2015.9.4.379. Epub 2015 Jun 19.
BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program.
SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: 57 ± 8 years) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification.
RESULTS
Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, 126 ± 68 mg/dl; TC, 134 ± 74 mg/dl; and CC, 172 ± 101 mg/dl. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: -21.9 ± 61.0 mg/dl, -20.9 ± 51.0 mg/dl, and -42.6 ± 78.5 mg/dl, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.
CONCLUSIONS
The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.
背景/目的：载脂蛋白A5基因启动子区域T-1131C多态性（APOA5 T-1131C）已知与血浆甘油三酯（TG）水平升高有关，尽管关于APOA5 T-1131C与生活方式改变之间的相互作用对TG水平的影响知之甚少。为了研究这个问题，我们对参与一项为期三个月生活方式改变计划的受试者的APOA5 T-1131C和血浆TG水平进行了研究。
受试者/方法：2001年至2007年，在日本出云市对297名参与者（年龄：57±8岁）进行了一项为期三个月的生活方式改变计划。能量平衡的变化（能量摄入与能量消耗之间的差异）和体重指数（BMI）用于评估参与者对生活方式改变的反应。
结果
即使在对混杂因素进行调整后，三个基因型亚组在基线时的血浆TG水平仍有显著差异：TT组为126±68mg/dl；TC组为134±74mg/dl；CC组为172±101mg/dl。生活方式改变导致TT、TC和CC基因型亚组的血浆TG水平显著降低：分别为-21.9±61.0mg/dl、-20.9±51.0mg/dl和-42.6±78.5mg/dl，它们之间无显著差异。在逐步回归分析中，年龄、APOA5 T-1131C、体重指数（BMI）、稳态模型评估-胰岛素抵抗（HOMA-IR）和18:1/18:0比值在基线时与血浆TG水平呈独立相关。在一般线性模型分析中，在对年龄、性别和基线血浆TG水平进行调整后，APOA5 T-1131C C等位基因携带者与野生型携带者相比，随着能量平衡的降低，TG降低更为显著。
结论
APOA5 T-1131C的基因效应独立影响血浆TG水平。然而，尽管有APOA5 T-1131C基因型背景，生活方式改变在显著降低血浆TG水平方面仍然有效。
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