Simmonds E, Alfaham M, Prosser R, Penney M D
Department of Paediatrics, Royal Gwent Hospital, Newport.
Arch Dis Child. 1989 Dec;64(12):1717-20. doi: 10.1136/adc.64.12.1717.
After pilocarpine iontophoresis the change of sweat concentration during collection was studied by vapour pressure osmometry in 24 patients with cystic fibrosis and 24 healthy controls. There was a continuous but proportionate fall in sweat concentrations during the collection period. Mean (SD) initial sweat concentration in the control group was 154.4 (32.6) mmol/kg falling, after 50 microliters of sweat produced, to 92.9 (15.8) mmol/kg. In the cystic fibrosis group it was 315.9 (35.8) mmol/kg falling to 247.4 (24.9) mmol/kg. Despite different rates of fall in concentrations, separation of the two groups was maintained throughout. We conclude that there are implications for the potential improvement of the predictive value of the sweat test.
在毛果芸香碱离子导入后，通过蒸汽压渗量法研究了24例囊性纤维化患者和24例健康对照者汗液收集过程中汗液浓度的变化。在收集期间，汗液浓度持续但成比例下降。对照组平均（标准差）初始汗液浓度为154.4（32.6）mmol/kg，在产生50微升汗液后，降至92.9（15.8）mmol/kg。在囊性纤维化组中，初始浓度为315.9（35.8）mmol/kg，降至247.4（24.9）mmol/kg。尽管浓度下降速率不同，但两组在整个过程中仍保持分离。我们得出结论，这对汗液试验预测价值的潜在提高具有启示意义。
