Zarkovic J, Eichler I, Roscher A, Götz M
Padiatr Padol. 1987;22(2):157-62.
Two methods of sweat testing (Gibson and Cooke's vs. sweat osmolality) for the diagnosis of cystic fibrosis were compared in 33 subjects (26 healthy subjects and 7 patients aged 23 days to 28 years). Sweat was collected with a "macroduct"-sweat collection-system, osmolality was measured with the Wescorvapor-pressure osmometry. In a further 18 subjects (13 healthy, 5 patients) electrolytes were determined from filter-paper and the Vescor-macroduct-system. The osmolality in sweat of healthy subjects and patients with CF differed significantly (p less than 0.001). In healthy subjects maximum osmolality was 198 mmol/kg (means 158 +/- 21.3 mmol/kg), in patients with CF 283.9 +/- 10.2 mmol/kg. Assessment of sweat osmolality is a highly reliable procedure for confirming the diagnosis of CF provided borderline-values between 180 and 220 mmol/kg are reevaluated with the conventional filter-paper assay.
在33名受试者（26名健康受试者和7名年龄在23天至28岁之间的患者）中比较了两种用于诊断囊性纤维化的汗液检测方法（吉布森和库克方法与汗液渗透压检测法）。使用“大导管”汗液收集系统收集汗液，用韦斯科普夫蒸气压渗透压计测量渗透压。在另外18名受试者（13名健康者，5名患者）中，通过滤纸和韦斯科普夫 - 大导管系统测定电解质。健康受试者和囊性纤维化患者汗液中的渗透压差异显著（p<0.001）。健康受试者汗液的最大渗透压为198 mmol/kg（平均158±21.3 mmol/kg），囊性纤维化患者为283.9±10.2 mmol/kg。如果180至220 mmol/kg之间的临界值用传统滤纸检测法重新评估，那么评估汗液渗透压是确诊囊性纤维化的高度可靠方法。
