1 型糖尿病与 microRNA：错综复杂。

Type 1 Diabetes and MicroRNA: It's Complicated.

机构信息

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Cell Metab. 2015 Aug 4;22(2):202-3. doi: 10.1016/j.cmet.2015.07.018.

DOI:10.1016/j.cmet.2015.07.018

PMID:26244930

Abstract

Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRNA and the DNA damage checkpoint pathway.

摘要

1 型糖尿病是一种自身免疫性疾病，表现为胰岛素分泌受损，随着时间的推移会出现多种并发症。Bhatt 等人（2015 年）使用诱导多能干细胞作为遗传模型研究 1 型糖尿病幸存者的保护机制，揭示了 microRNA 与 DNA 损伤检查点途径之间的新相互作用。