Wu Bin, Miller Daniel
Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, 295 Xichang Rd., Wuhua Qu, Kunming, Yunnan, 650031, China.
School of Computing, University of South Alabama, Mobile, AL, 36688, USA.
Methods Mol Biol. 2017;1617:225-239. doi: 10.1007/978-1-4939-7046-9_17.
Diabetes is a severe condition worldwide. It is characterized by chronic hyperglycemia and is caused by defects in insulin production, secretion, and action. Both genetic and environmental factors contribute to the development of type 1 and type 2 diabetes. The pathogenesis of diabetes is complex and the underlying molecular mechanisms are only partially understood. MicroRNAs (miRNAs) play a fundamental role in diabetes and its complications. This chapter focuses on the dysregulation of miRNAs involved in the regulation of pancreatic islet insulin production and secretion as well as action and signaling in peripheral tissues. The roles of miRNAs in the development of diabetic complications are also discussed. Modulating miRNA expression, by either upregulation or inhibition, holds a promise as a strategy for treating this metabolic disease.
糖尿病是一种在全球范围内的严重病症。其特征为慢性高血糖，由胰岛素产生、分泌及作用方面的缺陷所致。遗传和环境因素均促使1型和2型糖尿病的发生。糖尿病的发病机制复杂，其潜在分子机制仅得到部分理解。微小RNA（miRNA）在糖尿病及其并发症中发挥着重要作用。本章聚焦于参与调节胰岛胰岛素产生、分泌以及外周组织中作用和信号传导的miRNA失调情况。还讨论了miRNA在糖尿病并发症发生发展中的作用。通过上调或抑制来调节miRNA表达，有望成为治疗这种代谢性疾病的一种策略。
