2011年马鲁蒂基督复临医院患者尿路病原体的抗菌药敏谱

Antimicrobial susceptibility profile of uropathogens in Maluti Adventist Hospital patients, 2011.

作者信息

Mubanga Phillip, Steinberg Wilhelm J, Van Rooyen Francois C

机构信息

Faculty of Health Sciences, Department of Family Medicine, University of the Free State.

出版信息

Afr J Prim Health Care Fam Med. 2015 May 12;7(1):800. doi: 10.4102/phcfm.v7i1.800.

DOI:10.4102/phcfm.v7i1.800

PMID:26245603

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4683433/

Abstract

BACKGROUND

Urinary tract infections (UTIs) are amongst the most common infections encountered globally and are usually treated empirically based on bacterial resistance to antibiotics for a given region. Unfortunately in Lesotho, no published studies are available to guide doctors in the treatment of UTIs. Treatment protocols for Western countries have been adopted, which may not be applicable for this region.

AIM

To determine the antimicrobial susceptibility profile of uropathogens in outpatients at the Maluti Adventist Hospital.

SETTING

The study was conducted at the outpatient department of the Maluti Adventist Hospital in Mapoteng, Lesotho.

METHODS

This was a prospective cross-sectional study using consecutive sampling of patients with clinical symptoms of UTI. Midstream urine samples were screened through chemistry and microscopy, then positive urine samples were cultured. The isolated uropathogens underwent antimicrobial susceptibility testing and inclusion continued until 200 culture samples were obtained. Descriptive statistics were used in the data analysis.

RESULTS

The top five cultured uropathogens were Escherichia coli (61.5%), Staphylococcus aureus (14%), Pseudomonasspecies (6.5%), Enterococcus faecalis (5.5%) and Streptococcus agalactiae (5%). The isolated uropathogens showed low sensitivity to cotrimoxazole (32.5%-75.0%) and amoxicillin (33.2%-87.5%) and high sensitivity to ciprofloxacin (84.0%-95.1%) and nitrofurantoin (76.9%-100%).

CONCLUSION

In the Maluti setting, cotrimoxazole and amoxicillin should be avoided as first-line drugs for the empirical treatment of community-acquired UTI. We recommend the use of nitrofurantoin as first choice.

摘要

背景

尿路感染（UTIs）是全球最常见的感染之一，通常根据特定地区细菌对抗生素的耐药性进行经验性治疗。不幸的是，在莱索托，尚无已发表的研究可指导医生治疗UTIs。西方国家的治疗方案已被采用，但可能不适用于该地区。

目的

确定马鲁蒂基督复临医院门诊患者尿路病原体的抗菌药敏谱。

地点

该研究在莱索托马波滕的马鲁蒂基督复临医院门诊部进行。

方法

这是一项前瞻性横断面研究，采用连续抽样的有UTI临床症状的患者。通过化学和显微镜检查对中段尿样本进行筛查，然后对阳性尿样本进行培养。对分离出的尿路病原体进行抗菌药敏试验，持续纳入直至获得200份培养样本。数据分析采用描述性统计。

结果

培养出的前五种尿路病原体为大肠杆菌（61.5%）、金黄色葡萄球菌（14%）、假单胞菌属（6.5%）、粪肠球菌（5.5%）和无乳链球菌（5%）。分离出的尿路病原体对复方新诺明（32.5%-75.0%）和阿莫西林（33.2%-87.5%）敏感性较低，对环丙沙星（84.0%-95.1%）和呋喃妥因（76.9%-100%）敏感性较高。