Park Eliza M, Rosenstein Donald L
Department of Psychiatry University of North Carolina, Chapel Hill, North Carolina, USA.
Department of Psychiatry and Department of Medicine University of North Carolina, Chapel Hill, North Carolina, USA.
Dialogues Clin Neurosci. 2015 Jun;17(2):171-80. doi: 10.31887/DCNS.2015.17.2/epark.
Adolescents and young adults (AYAs) with cancer are at risk for depression due to disruptions in their developmental trajectory, greater physical symptom burden, and increased likelihood of developing aggressive disease. Rates of depression and other psychological disorders are substantially higher in AYAs with cancer when compared with older adults. Psychiatrists caring for these patients must consider the age-appropriate developmental context of these patients along with familial and medical factors that may influence the presentation and treatment of depression. Previous research suggests that psychosocial interventions specifically designed for AYA patients are promising, but studies of psychopharmacology treatments for depression are lacking. There is a pressing need for prospective studies and controlled clinical trials that evaluate the optimal strategies for treating depression in this patient group.
患有癌症的青少年和青年（AYA）由于其发育轨迹中断、身体症状负担加重以及罹患侵袭性疾病的可能性增加，面临着抑郁风险。与老年人相比，患有癌症的AYA出现抑郁和其他心理障碍的几率要高得多。照料这些患者的精神科医生必须考虑这些患者适合其年龄的发育背景以及可能影响抑郁表现和治疗的家庭及医疗因素。先前的研究表明，专门为AYA患者设计的心理社会干预措施前景良好，但缺乏针对抑郁症的精神药理学治疗研究。迫切需要进行前瞻性研究和对照临床试验，以评估治疗该患者群体抑郁症的最佳策略。
