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氯胺酮滥用综合征:纽约法拉盛青少年的肝胆及泌尿系统病理学研究

Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.

作者信息

Wang Jessica W, Kivovich Violetta, Gordon Laurie

机构信息

From the *New York Presbyterian Hospital, New York; and †New York Hospital Queens, Flushing, NY.

出版信息

Pediatr Emerg Care. 2017 Aug;33(8):e24-e26. doi: 10.1097/PEC.0000000000000502.

DOI:10.1097/PEC.0000000000000502
PMID:26247263
Abstract

OBJECTIVES

Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States. Many US clinicians are unaware of abuse symptoms, leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical patterns that should alert a clinician to the possibility of ketamine abuse.

METHODS

We present 6 adolescent patients who presented to the pediatric emergency department and inpatient wards with urinary and hepatobiliary symptoms in the setting of ketamine abuse.

RESULTS

We identified 6 patients with confirmed ketamine abuse who presented with epigastric pain or urinary pain. All had laboratory and radiographic evidence of disease.

CONCLUSIONS

Ketamine abuse is associated with a distinctive pattern of symptoms involving the urinary and hepatobiliary systems.

摘要

目的

氯胺酮是一种在东亚以及美国某些亚人群中被广泛滥用的娱乐性药物。许多美国临床医生并不了解其滥用症状,从而导致误诊以及错过干预时机。我们将讨论一些临床症状模式,这些模式应能提醒临床医生注意氯胺酮滥用的可能性。

方法

我们介绍了6名青少年患者,他们因氯胺酮滥用出现泌尿和肝胆系统症状,前来儿科急诊科和住院病房就诊。

结果

我们确定了6名确诊氯胺酮滥用的患者,他们均表现为上腹部疼痛或尿痛。所有人都有疾病的实验室和影像学证据。

结论

氯胺酮滥用与涉及泌尿和肝胆系统的独特症状模式有关。

相似文献

1
Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.氯胺酮滥用综合征:纽约法拉盛青少年的肝胆及泌尿系统病理学研究
Pediatr Emerg Care. 2017 Aug;33(8):e24-e26. doi: 10.1097/PEC.0000000000000502.
2
Illicit ketamine and its bladder consequences: is it irreversible?非法氯胺酮及其对膀胱的影响:是否不可逆?
BMJ Case Rep. 2012 Oct 30;2012:bcr2012007244. doi: 10.1136/bcr-2012-007244.
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The prevalence and natural history of urinary symptoms among recreational ketamine users.娱乐性氯胺酮使用者的尿路症状的流行率和自然史。
BJU Int. 2012 Dec;110(11):1762-6. doi: 10.1111/j.1464-410X.2012.11028.x. Epub 2012 Mar 14.
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Ketamine-associated lower urinary tract destruction: a new radiological challenge.氯胺酮相关性下尿路破坏:一种新的影像学挑战。
Clin Radiol. 2010 Oct;65(10):795-800. doi: 10.1016/j.crad.2010.05.003. Epub 2010 Jul 29.
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Dependence and urinary symptoms among recreational ketamine users.娱乐性氯胺酮使用者的依赖性及泌尿症状
BJU Int. 2013 Mar;111(3):E21-2. doi: 10.1111/bju.12020_14.
6
Re: The prevalence and natural history of urinary symptoms among recreational ketamine users.关于:娱乐性氯胺酮使用者泌尿系统症状的患病率及自然史。
J Urol. 2013 Nov;190(5):1816. doi: 10.1016/j.juro.2013.07.091. Epub 2013 Aug 2.
7
Re: the prevalence and natural history of urinary symptoms among recreational ketamine users.关于:娱乐性氯胺酮使用者泌尿系统症状的患病率及自然病史。
J Urol. 2013 Aug;190(2):551. doi: 10.1016/j.juro.2013.04.069. Epub 2013 Apr 27.
8
[Ketamine-associated urinary tract damage].[氯胺酮相关的尿路损伤]
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):636-9.
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Genitourinary toxicity of ketamine.氯胺酮的泌尿生殖系统毒性。
Hong Kong Med J. 2013 Aug;19(4):341-8. doi: 10.12809/hkmj134013. Epub 2013 Jul 8.
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[Ketamine-induced urinary symptoms].[氯胺酮诱发的泌尿系统症状]
Ugeskr Laeger. 2014 Feb 3;176(3):243-4.

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Efficacy and safety of ketamine for neonatal refractory status epilepticus: case report and systematic review.氯胺酮治疗新生儿难治性癫痫持续状态的疗效和安全性:病例报告及系统评价
Front Pediatr. 2023 Jun 2;11:1189478. doi: 10.3389/fped.2023.1189478. eCollection 2023.
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Repeated or Continuous Medically Supervised Ketamine Administration Associated with Hepatobiliary Adverse Events: A Retrospective Case Series.重复或连续的医学监督氯胺酮给药与肝胆不良事件相关:一项回顾性病例系列研究。
Drug Saf. 2021 Dec;44(12):1365-1374. doi: 10.1007/s40264-021-01120-9. Epub 2021 Oct 26.
3
gene reduces oxidative stress in the bladder by regulating the NF-κB pathway in a mouse model of ketamine-induced cystitis.
基因通过在氯胺酮诱导的膀胱炎小鼠模型中调节NF-κB信号通路来减轻膀胱中的氧化应激。
Exp Ther Med. 2020 Nov;20(5):111. doi: 10.3892/etm.2020.9239. Epub 2020 Sep 18.
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Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction.氯胺酮诱导的排尿功能障碍小鼠模型中的完整尿路上皮屏障功能
Am J Physiol Renal Physiol. 2016 May 1;310(9):F885-94. doi: 10.1152/ajprenal.00483.2015. Epub 2016 Feb 24.