钯催化由炔丙酰胺基芳基三氟甲磺酸酯一锅法合成3-（二芳基亚甲基）氧化吲哚

Lee Dahye, Park Sunhwa, Yu Yoseb, Shin Kye Jung, Seo Jae Hong

Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea.

Molecules. 2015 Aug 3;20(8):14022-32. doi: 10.3390/molecules200814022.

3-(Diarylmethylene)oxindoles have been synthesized from propiolamidoaryl triflate utilizing a palladium-catalyzed one-pot reaction consisting of three successive reactions: Sonogashira, Heck, and Suzuki-Miyaura. This method allows for the production of a complex skeleton of 3-(diarylmethylene)oxindole from propiolamidoaryl triflate using a commercially available aryl iodide and arylboronic acid in a simple and efficient way with moderate yield and stereoselectivity.

利用钯催化的一锅反应，由炔丙酰胺基芳基三氟甲磺酸酯合成了3-（二芳基亚甲基）氧化吲哚，该反应由三个连续反应组成：Sonogashira反应、Heck反应和Suzuki-Miyaura反应。该方法能够以简单高效的方式，使用市售的芳基碘化物和芳基硼酸，从炔丙酰胺基芳基三氟甲磺酸酯制备3-（二芳基亚甲基）氧化吲哚的复杂骨架，产率和立体选择性适中。