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用于合成取代烯烃氧化吲哚的先进无钯方法——铝促进的克诺文纳格尔反应。

Advanced palladium free approach to the synthesis of substituted alkene oxindoles aluminum-promoted Knoevenagel reaction.

作者信息

Novikova Daria S, Grigoreva Tatyana A, Zolotarev Andrey A, Garabadzhiu Alexander V, Tribulovich Vyacheslav G

机构信息

Laboratory of Molecular Pharmacology, Saint Petersburg State Institute of Technology (Technical University) Moskovskii pr. 26 Saint Petersburg 190013 Russia

Department of Crystallography, Saint Petersburg State University per. Dekabristov 16 Saint Petersburg 199155 Russia.

出版信息

RSC Adv. 2018 Oct 10;8(60):34543-34551. doi: 10.1039/c8ra07576j. eCollection 2018 Oct 4.

DOI:10.1039/c8ra07576j
PMID:35548634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9086994/
Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

摘要

基于汇聚策略，开发了一种合成C24的路线以及直接AMPK激活剂聚焦文库的设计方法。所提出的方案符合C-H键官能化的当前趋势。使用异丙醇铝进行氧化吲哚与二苯甲酮的Knoevenagel缩合是这项工作的一个显著特点。

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