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A Novel Y319H Substitution in CYP51C Associated with Azole Resistance in Aspergillus flavus.

作者信息

Paul R A, Rudramurthy S M, Meis J F, Mouton J W, Chakrabarti A

机构信息

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.

出版信息

Antimicrob Agents Chemother. 2015 Oct;59(10):6615-9. doi: 10.1128/AAC.00637-15. Epub 2015 Jul 27.

DOI:10.1128/AAC.00637-15
PMID:26248359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4576050/
Abstract

This study aimed to explore any mutation in the CYP51 gene conferring azole resistance in Aspergillus flavus. Two voriconazole-resistant and 45 voriconazole-susceptible isolates were included in the study. Sequence analysis demonstrated a T1025C nucleotide change in CYP51C, resulting in the Y319H amino acid substitution in one resistant isolate. However, the earlier described T788G mutation in CYP51C conferring voriconazole resistance in A. flavus isolates was present in all isolates, irrespective of their susceptibility status.

摘要

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本文引用的文献

[1]
Epidemiology of chronic fungal rhinosinusitis in rural India.

Mycoses. 2015-5

[2]
Use of long term molecular dynamics simulation in predicting cancer associated SNPs.

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Antimicrob Agents Chemother. 2012-2-6

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J Antimicrob Chemother. 2011-10-25

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Diagn Microbiol Infect Dis. 2011-9-19

[10]
The structure-function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance.

Fungal Genet Biol. 2011-8-30

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