Chakrabarti Arunaloke, Rudramurthy Shivaprakash M, Panda Naresh, Das Ashim, Singh Amarjeet
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mycoses. 2015 May;58(5):294-302. doi: 10.1111/myc.12314. Epub 2015 Mar 10.
A descriptive epidemiological study of fungal rhinosinusitis (FRS) was conducted in rural north India in the form of house-to-house survey of villages of two districts each of Punjab and Haryana provinces using a clinical case definition of chronic rhinosinusitis (CRS). The suspected cases were investigated further in the laboratory to confirm FRS. Air and environment were sampled in different seasons to find Aspergillus spore count. The prevalence of chronic FRS cases was at 0.11% of the population and Aspergillus flavus was the predominant (97.6%) agent of all types of chronic FRS. The chronic FRS patients were classified as allergic FRS 41 (56.1%), chronic granulomatous FRS 13 (17.8%), eosinophilic FRS 11 (15.0%), fungal ball 7 (9.5%) and chronic invasive FRS 1 (1.3%). Aspergillus spores were present in large numbers (~20%) in air with significantly higher counts of A. flavus during winter months in the wheat-thrashing areas of Punjab as compared to Haryana (P = 0.0079). The present study identified high prevalence (27.5% of CRS cases) of chronic FRS cases in rural north India and its possible association with wheat harvesting seasons.
在印度北部农村地区开展了一项真菌性鼻窦炎（FRS）的描述性流行病学研究，采用慢性鼻窦炎（CRS）的临床病例定义，对旁遮普邦和哈里亚纳邦各两个区的村庄进行逐户调查。对疑似病例进行进一步实验室检查以确诊FRS。在不同季节采集空气和环境样本，以测定曲霉菌孢子计数。慢性FRS病例的患病率为人口的0.11%，黄曲霉是所有类型慢性FRS的主要病原体（97.6%）。慢性FRS患者分为变应性FRS 41例（56.1%）、慢性肉芽肿性FRS 13例（17.8%）、嗜酸性粒细胞性FRS 11例（15.0%）、真菌球7例（9.5%）和慢性侵袭性FRS 1例（1.3%）。空气中存在大量曲霉菌孢子（约20%），旁遮普邦小麦脱粒区冬季的黄曲霉计数显著高于哈里亚纳邦（P = 0.0079）。本研究确定了印度北部农村地区慢性FRS病例的高患病率（占CRS病例的27.5%）及其与小麦收获季节的可能关联。
