Immuno-electronmicroscopic studies after influenza vaccination of young and old individuals.

Authors examined the lymphocytes of young and old individuals after influenza vaccination. They stated that membrane bound surface IgG and IgM were detectable on the lymphocytes and occasionally on lymphoblasts in both the old and young age groups. In both age-groups intracytoplasmic tubulo-reticular structures (TRS) were seen in the lymphocytes and lymphoblasts. In young individuals TRS was present in the peroxidase positive cells, in the contrary in old persons TRS was never found in cells with surface immunoglobulins. In the TRS themselves peroxidase positive IgG and IgM could be detected.