de Bruijn I A, Remarque E J, Jol-van der Zijde C M, van Tol M J, Westendorp R G, Knook D L
Section of Gerontology and Geriatrics, Section of Immunology, Department of Paediatrics, Leiden University, The Netherlands.
J Infect Dis. 1999 Jan;179(1):31-6. doi: 10.1086/314540.
Doubt about the serologic efficacy of annually repeated influenza vaccination prompted investigations into the course of hemagglutination-inhibiting (HI), IgG, and IgA antibody titers and the IgG and IgA avidity index to influenza A/Taiwan/1/86 and A/Beijing/353/89 after annual vaccination. Fifty-four healthy elderly persons >70 years of age and 24 healthy young adults <30 years of age received standard influenza vaccine during 3 consecutive years. On average, prevaccination HI, IgG, and IgA titers to both influenza virus strains increased >=4 fold between the first and the third vaccination (analysis of variance, P<.001). The postvaccination HI and IgG titers remained unchanged after annual vaccination. The avidity index of IgG and IgA antibodies increased somewhat after annual vaccination, although the increase was statistically significant only in the young subjects. These data indicate that annual influenza vaccination of healthy elderly and young subjects results in an overall increase in protective antibodies.
对每年重复进行流感疫苗接种的血清学效力的怀疑促使人们对每年接种疫苗后针对甲型流感病毒/台湾/1/86株和甲型流感病毒/北京/353/89株的血凝抑制（HI）、IgG和IgA抗体滴度以及IgG和IgA亲和力指数的变化过程展开调查。54名年龄大于70岁的健康老年人和24名年龄小于30岁的健康年轻人连续3年接种标准流感疫苗。平均而言，在第一次和第三次接种之间，针对两种流感病毒株的接种前HI、IgG和IgA滴度均增加了≥4倍（方差分析，P<0.001）。每年接种疫苗后，接种后的HI和IgG滴度保持不变。每年接种疫苗后，IgG和IgA抗体的亲和力指数有所增加，尽管仅在年轻受试者中增加具有统计学意义。这些数据表明，对健康的老年人和年轻人每年进行流感疫苗接种会使保护性抗体总体增加。
