[Epidemiologic significance of persistent observation of serum HBV-DNA in asymptomatic HBsAg carriers].

Serum HBV-DNA was assayed in 65 asymptomatic HBsAg carriers (ASC) for one to two years. HBV replication marks, such as serum HBeAg, DNA polymerase, HBsAg-PHSA-R and liver function in the ASC with different types of the dynamic changes of HBV-DNA were determined and compared. The transmissive state in the family members of the ASC were investigated. The results showed that among the 65 ASC 27 cases (41.54%) were HBV-DNA persistently positive with marked infectivity, 21 cases (32.31%) were HBV-DNA persistently negative with lower infectivity 10 cases (15.38%) with HBV-DNA conversion from positive to negative and 7 cases (10.77%) with HBV-DNA conversion from negative to positive. It is of instructive significance in epidemiology.