Klempel K, Bleeker H E
Psychiatr Clin (Basel). 1979;12(4):216-32.
The lability of peripheral venous postabsorptive blood sugar regulation was investigated in 98 patients suffering from floridly psychotic diseases (45 somatically based psychoses, 27 endogenous/involutional depressions, and 26 schizophrenic psychoses). In total, 259 times, in 30-sec intervals, 10 fasting blood sugar values each were determined (so-called 'Anderson curves'). The maximal normal range of 36 mg% of spontaneous blood sugar oscillations in normal probands was exceeded in 17% of depressive, in 15% of schizophrenic, and in 12% of somatically based psychoses. The frequency and probability of appearance of pathological Anderson curves proved independently of any clinical-psychiatric diagnosis, and only significantly correlated with the criterion 'psychotically ill'. Discussed are primary central deviations from nominal gluco-sensitive regulatory 'tone' as postulated cause of pathological lability of venous blood sugar homeostasis resulting. Besides additional, pre-known glucose-metabolic derangements accompanying certain neuropsychiatric syndromes, pathological Anderson curves in psychotic illness are looked at as unspecific functional deviations involving bipolar-adrenergic dysbalances.
对98例患有明显精神疾病的患者（45例躯体性精神病、27例内源性/更年期抑郁症和26例精神分裂症）的外周静脉吸收后血糖调节的不稳定性进行了研究。总共259次，每隔30秒测定10次空腹血糖值（即所谓的“安德森曲线”）。正常受试者自发血糖波动的最大正常范围为36mg%，在17%的抑郁症患者、15%的精神分裂症患者和12%的躯体性精神病患者中超过了该范围。病理性安德森曲线出现的频率和概率与任何临床精神病学诊断无关，仅与“精神病性疾病”标准显著相关。讨论了原发性中枢偏离标称的葡萄糖敏感调节“基调”，这被假定为静脉血糖稳态病理性不稳定的原因。除了某些神经精神综合征伴随的额外的、已知的葡萄糖代谢紊乱外，精神病性疾病中的病理性安德森曲线被视为涉及双相肾上腺素失衡的非特异性功能偏差。
