DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
作者信息
Nangalia Jyoti, Nice Francesca L, Wedge David C, Godfrey Anna L, Grinfeld Jacob, Thakker Clare, Massie Charlie E, Baxter Joanna, Sewell David, Silber Yvonne, Campbell Peter J, Green Anthony R
机构信息
Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
出版信息
Haematologica. 2015 Nov;100(11):e438-42. doi: 10.3324/haematol.2015.129510. Epub 2015 Aug 6.
Abstract
摘要
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本文引用的文献
1
Effect of mutation order on myeloproliferative neoplasms.
N Engl J Med. 2015 Feb 12;372(7):601-612. doi: 10.1056/NEJMoa1412098.
2
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26.
3
Age-related clonal hematopoiesis associated with adverse outcomes.
N Engl J Med. 2014 Dec 25;371(26):2488-98. doi: 10.1056/NEJMoa1408617. Epub 2014 Nov 26.
4
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.
Nature. 2014 Feb 20;506(7488):328-33. doi: 10.1038/nature13038. Epub 2014 Feb 12.
5
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.
Blood. 2014 Apr 3;123(14):2220-8. doi: 10.1182/blood-2013-11-537167. Epub 2014 Jan 29.
6
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
N Engl J Med. 2013 Dec 19;369(25):2391-2405. doi: 10.1056/NEJMoa1312542. Epub 2013 Dec 10.
7
Dnmt3a is essential for hematopoietic stem cell differentiation.
Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009.
8
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Haematologica. 2012 Feb;97(2):246-50. doi: 10.3324/haematol.2011.051581. Epub 2011 Oct 11.
9
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice.
Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71. doi: 10.1073/pnas.1112317108. Epub 2011 Aug 22.
10
Clonal and lineage analysis of somatic DNMT3A and JAK2 mutations in a chronic phase polycythemia vera patient.
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