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DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

作者信息

Nangalia Jyoti, Nice Francesca L, Wedge David C, Godfrey Anna L, Grinfeld Jacob, Thakker Clare, Massie Charlie E, Baxter Joanna, Sewell David, Silber Yvonne, Campbell Peter J, Green Anthony R

机构信息

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.

出版信息

Haematologica. 2015 Nov;100(11):e438-42. doi: 10.3324/haematol.2015.129510. Epub 2015 Aug 6.

DOI:10.3324/haematol.2015.129510
PMID:26250577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4825297/
Abstract
摘要

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本文引用的文献

1
Effect of mutation order on myeloproliferative neoplasms.突变顺序对骨髓增殖性肿瘤的影响。
N Engl J Med. 2015 Feb 12;372(7):601-612. doi: 10.1056/NEJMoa1412098.
2
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.从血液DNA序列推断克隆性造血与血癌风险。
N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26.
3
Age-related clonal hematopoiesis associated with adverse outcomes.与不良预后相关的年龄相关性克隆性造血。
N Engl J Med. 2014 Dec 25;371(26):2488-98. doi: 10.1056/NEJMoa1408617. Epub 2014 Nov 26.
4
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.急性白血病中白血病前造血干细胞的鉴定。
Nature. 2014 Feb 20;506(7488):328-33. doi: 10.1038/nature13038. Epub 2014 Feb 12.
5
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.骨髓增殖性肿瘤体细胞突变的克隆进化及其临床相关性。
Blood. 2014 Apr 3;123(14):2220-8. doi: 10.1182/blood-2013-11-537167. Epub 2014 Jan 29.
6
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.伴有未突变 JAK2 的骨髓增殖性肿瘤中的体细胞 CALR 突变。
N Engl J Med. 2013 Dec 19;369(25):2391-2405. doi: 10.1056/NEJMoa1312542. Epub 2013 Dec 10.
7
Dnmt3a is essential for hematopoietic stem cell differentiation.DNMT3A 对于造血干细胞的分化是必不可少的。
Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009.
8
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.治疗相关性和继发性急性髓系白血病中体细胞 DNMT3A 突变的频率、发病机制和临床影响。
Haematologica. 2012 Feb;97(2):246-50. doi: 10.3324/haematol.2011.051581. Epub 2011 Oct 11.
9
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice.TET2 基因的十十一易位 2 负向调控了小鼠造血干细胞的自我更新和分化。
Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71. doi: 10.1073/pnas.1112317108. Epub 2011 Aug 22.
10
Clonal and lineage analysis of somatic DNMT3A and JAK2 mutations in a chronic phase polycythemia vera patient.一名慢性期真性红细胞增多症患者体细胞DNMT3A和JAK2突变的克隆及谱系分析
Br J Haematol. 2012 Jan;156(2):268-70. doi: 10.1111/j.1365-2141.2011.08837.x. Epub 2011 Aug 22.