[Lipid free-radical oxidation in rats with alimentary hypercholesterolemia and its correction with ceruloplasmin].

The antioxidant enzyme ceruloplasmin effect on the state of lipid and peroxide metabolism in rats with alimentary hypercholesterolemia was studied. Ceruloplasmin was found to inhibit the development of hyperlipoproteinemia, to decrease the level of free-radical oxidation of lipids and to increase the antioxidant demands of tissues. The observed effects could be explained by the antioxidant properties of ceruloplasmin.