Kong Weiqi, Zhang Yanyan, Gong Yunhui, Dai Li, Zhou Rong
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Aug;32(4):543-7. doi: 10.3760/cma.j.issn.1003-9406.2015.04.021.
To assess the association of prostasin gene rs12597511 polymorphism with clinical features and pregnancy outcomes among patients with severe preeclampsia.
Clinical manifestations, pregnancy outcomes and the genotypes of 179 patients with severe preeclampsia [early-onset group (≤34 gestational weeks): 79 cases; Late-onset group (>34 gestational weeks): 100 cases] and 222 normal-term pregnant women (control group) were collected.
In the early-onset group, the patients with TC or CC genotype at rs12597511 had higher incidences of total complications, liver dysfunction, neonatal asphyxia, neonatal intracranial hemorrhage and perinatal mortality compared with those with TT genotype (P>0.05). Multiple logistic regression analysis showed that the complication rates of severe preeclampsia patients are closely related to TC or CC genotypes, 24 h urinary protein and gestational weeks of onset (OR=1.049, 95% CI:1.007-1.093, P=0.021; OR=1.031, 95% CI: 0.350-0.883, P=0.013; OR=0.733, 95% CI: 0.566-0.950, P=0.019), and the perinatal mortality is related to gestational weeks at delivery (OR=0.542, 95% CI: 0.331-0.887, P=0.015).
Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.
评估严重子痫前期患者中前列腺素基因rs12597511多态性与临床特征及妊娠结局的相关性。
收集179例严重子痫前期患者[早发型组（孕周≤34周）：79例；晚发型组（孕周>34周）：100例]及222例足月孕妇（对照组）的临床表现、妊娠结局及基因型。
在早发型组中，rs12597511位点TC或CC基因型患者的总并发症、肝功能障碍、新生儿窒息、新生儿颅内出血及围产儿死亡率的发生率高于TT基因型患者（P>0.05）。多因素logistic回归分析显示，严重子痫前期患者的并发症发生率与TC或CC基因型、24小时尿蛋白及发病孕周密切相关（OR=1.049，95%CI：1.007-1.093，P=0.021；OR=1.031，95%CI：0.350-0.883，P=0.013；OR=0.733，95%CI：0.566-0.950，P=0.019），围产儿死亡率与分娩孕周相关（OR=0.542，95%CI：0.331-0.887，P=0.015）。
前列腺素基因多态性与早发型严重子痫前期不良妊娠结局密切相关。
