Luo Dong, Zhang Yanyan, Bai Yi, Liu Xijing, Gong Yunhui, Zhou Bin, Zhang Lin, Luo Linli, Zhou Rong
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Chin Med J (Engl). 2014;127(11):2048-52.
Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and metastasis and influences blood pressure through activating epithelial sodium channel. The effect of prostasin on the pathogenesis of preeclampsia remains unclear. This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia.
A single nucleotide polymorphism, rs12597511, was tested with polymerase chain reaction and restrictionfragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women.
The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030, 95% confidence interval 1.195-3.449, P = 0.009). The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P = 0.001). Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia.
The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.
子痫前期以高血压和蛋白尿为特征，是一种与滋养层细胞浅侵入和螺旋动脉重塑不足相关的多因素疾病。滋养层细胞和肿瘤细胞具有相似的侵袭机制。前列腺素酶与肿瘤发展、侵袭和转移密切相关，并通过激活上皮钠通道影响血压。前列腺素酶在子痫前期发病机制中的作用尚不清楚。本研究调查了前列腺素酶基因rs12597511与重度子痫前期的关联。
采用聚合酶链反应和限制性片段长度多态性分析，对179例重度子痫前期患者和222例正常孕妇进行单核苷酸多态性rs12597511检测。
重度子痫前期组TC + CC基因型频率显著高于对照组（校正优势比为2.030，95%置信区间为1.195 - 3.449，P = 0.009）。rs12597511的C等位基因在重度子痫前期女性中出现的频率显著更高（P = 0.001）。基因分型分析表明，rs12597511的C等位基因可能会增加重度子痫前期的发病风险。
前列腺素酶基因rs12597511的C等位基因频率较高与重度子痫前期有关。
