Wang Wei, Tian Xueye, Zhang Ting, Wang Yanyan, Han Zhen, An Ruifang
Obstetrics and Gynecology Department, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
Dis Markers. 2015;2015:917687. doi: 10.1155/2015/917687. Epub 2015 Jul 16.
In the present study, the three-dimensional power Doppler was used as a quantitative method to evaluate its reliability in detecting and assessing of gestational trophoblastic disease (GTD).
52 GTD patients who received diagnosis and treatment at the first affiliated hospitals of Xi'an Jiaotong University in China between 2011 and 2013 were evaluated using Voluson E8 (GE Medical System). Demographic information, pathological characteristics, clinical history, sonographic images, and related indices (resistance index, vascularization index, and flow and vascularization index) were evaluated.
Three-dimension power Doppler indicated that there were significant differences in the resistance index, vascularization index, flow index, and vascularization-flow index between the healthy individuals and each subgroup of patients (P < 0.01). Further, in combining invasive hydatidiform mole and choriocarcinoma groups, there was a significant difference between hydatidiform mole and the combined malignant group (P < 0.01). And the abnormal sonographic and power Doppler findings in GTD were resolved when chemotherapy was done successfully.
Combined with the clinical features, sonography and three-dimension power Doppler imaging were helpful in diagnosing GTD as a noninvasive method, distinguishing the invasive nature of disease, detecting the recurrence of the disease, and assessing the effectiveness of the chemotherapy.
在本研究中，三维能量多普勒被用作一种定量方法，以评估其在检测和评估妊娠滋养细胞疾病（GTD）方面的可靠性。
对2011年至2013年期间在中国西安交通大学第一附属医院接受诊断和治疗的52例GTD患者使用Voluson E8（GE医疗系统）进行评估。评估了人口统计学信息、病理特征、临床病史、超声图像以及相关指标（阻力指数、血管化指数、血流和血管化指数）。
三维能量多普勒显示，健康个体与各患者亚组之间的阻力指数、血管化指数、血流指数和血管化-血流指数存在显著差异（P<0.01）。此外，在侵袭性葡萄胎和绒毛膜癌合并组中，则葡萄胎与合并恶性组之间存在显著差异（P<0.01）。并且当化疗成功完成时，GTD中异常的超声和能量多普勒表现得到缓解。
结合临床特征，超声检查和三维能量多普勒成像作为一种非侵入性方法有助于诊断GTD、区分疾病的侵袭性、检测疾病的复发以及评估化疗效果。
