微小RNA生物合成在脂肪细胞和脂肪营养不良中的作用。
Role of microRNA biogenesis in adipocyte and lipodystrophy.
作者信息
Xu Dan, Sun Lei
机构信息
Cardiovascular and Metabolic Disorders; Duke-National University of Singapore Graduate Medical School ; Singapore.
Cardiovascular and Metabolic Disorders; Duke-National University of Singapore Graduate Medical School ; Singapore ; Institute of Molecular and Cell Biology ; Proteos; Singapore.
出版信息
Adipocyte. 2015 Jan 20;4(3):222-4. doi: 10.1080/21623945.2014.995507. eCollection 2015 Jul-Sep.
The detailed mechanism underlying adipocyte development and function remains to be fully understood. MicroRNAs are a class of non-coding regulators in adipocyte development and function in physiological and pathological conditions. Our recent study(11) using adipose-specific dgcr8 knockout mice demonstrates that microRNA biogenesis has a depot-specific function in adipose and plays an important role in brown adipocyte feature maintenance. Interestingly, in a parallel study from Kahn's group, Mori et al observed similar phenotypes in adipose-specific Dicer knockout mice. This study also reveals that the expression of Dicer is downregulated in the adipose from patients with HIV-associated lipodystrophy (HALS), suggesting that dysregulation of microRNA biogenesis may play a role in the onset of HALS.
脂肪细胞发育和功能的详细机制仍有待充分了解。微小RNA是一类在生理和病理条件下参与脂肪细胞发育和功能的非编码调节因子。我们最近利用脂肪特异性Dgcr8基因敲除小鼠进行的研究（11）表明，微小RNA的生物合成在脂肪组织中具有特定部位的功能，并且在棕色脂肪细胞特征维持中发挥重要作用。有趣的是，在Kahn团队的一项平行研究中，Mori等人在脂肪特异性Dicer基因敲除小鼠中观察到了类似的表型。该研究还表明，在与HIV相关的脂肪营养不良（HALS）患者的脂肪组织中，Dicer的表达下调，这表明微小RNA生物合成的失调可能在HALS的发病中起作用。
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