Ismerim Adna B, Ferreira Stephany V, Lessa Anne M G, Pereira Júnior Aderbal S, Gurgel Clarissa A, Coutinho-Camillo Claudia M, Soares Fernando A, Vilas-Bôas Deise S, Vidal Manuela T A, Santos Jean N D
*Dentistry and Health Post Graduation Program, School of Dentistry, Federal University of Bahia †School of Dentistry, Federal University of Bahia ∥Department of Biomorphology, Institute of Health Sciences, Federal University of Bahia Salvador, Bahia ‡Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia and Human Pathology Postgraduation Program, Fiocruz, Salvador, Bahia §A.C. Camargo Center Cancer, São Paulo-SP, Brazil.
Appl Immunohistochem Mol Morphol. 2016 Jul;24(6):422-6. doi: 10.1097/PAI.0000000000000205.
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is strongly expressed in malignant tumors and has been associated with their aggressive behavior. The aim of this study was to evaluate the presence of IMP3 in a series of salivary gland tumors. The sample consisted of 9 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 13 mucoepidermoid carcinomas (MEC) that were investigated by immunohistochemical technique. All cases of PA and MEC were positive for IMP3 particularly in the cytoplasm. PA showed 4 cases as high expression and 6 as low expression. MEC showed 10 cases as low expression and 3 as high expression. For ACC, 4 cases were high expression, whereas 6 cases were low expression. No significant difference was observed between tumors (P>0.05, Fisher's test) when both scores of IMP3 were compared. This study showed that MEC seems to be more sensitive to IMP3 than ACC and provided an insight into this protein in salivary gland tumors. Furthermore, although IMP3 is not a specific diagnostic marker to distinguish the tumors studied, it seems to mediate cell adhesion and migration in these tumors. Further studies should be performed to better understand the IMP3 biology in salivary gland tumors.
胰岛素样生长因子II信使核糖核酸结合蛋白3（IMP3）在恶性肿瘤中强烈表达，并与其侵袭性行为相关。本研究的目的是评估IMP3在一系列涎腺肿瘤中的存在情况。样本包括9例多形性腺瘤（PA）、14例腺样囊性癌（ACC）和13例黏液表皮样癌（MEC），采用免疫组织化学技术进行研究。所有PA和MEC病例的IMP3均呈阳性，尤其在细胞质中。PA显示4例高表达，6例低表达。MEC显示10例低表达，3例高表达。对于ACC，4例高表达，6例低表达。比较IMP3的两个评分时，肿瘤之间未观察到显著差异（P>0.05，Fisher检验）。本研究表明，MEC似乎比ACC对IMP3更敏感，并对涎腺肿瘤中的这种蛋白提供了深入了解。此外，尽管IMP3不是区分所研究肿瘤的特异性诊断标志物，但它似乎在这些肿瘤中介导细胞黏附和迁移。应进行进一步研究以更好地了解IMP3在涎腺肿瘤中的生物学特性。
