Foshan Fetal Medicine Research Institute, Affiliated Foshan Women and Children Hospital, Southern Medical University, Foshan, Guangdong, China.
Department of Obstetrics, Affiliated Foshan Women and Children Hospital, Southern Medical University, Foshan, Guangdong, China.
J Glob Health. 2023 Jun 23;13:04067. doi: 10.7189/jogh.13.04067.
Multiple studies and meta-analyses have claimed that breastfeeding is inversely correlated with maternal and childhood cancers. These results could either be causal or confounded by shared risk factors. By conducting an umbrella review, we aimed to consolidate the relationship between breastfeeding and maternal and childhood cancers.
We searched PubMed, Embase, Web of Science, Elsevier ScienceDirect, and Cochrane Library databases from inception to December 2022. Two reviewers independently extracted the data and assessed the quality of the studies using standardised forms. We considered two types of breastfeeding comparisons ("ever" vs "never" breastfeeding; and "longest" vs "shortest" duration). We estimated the pooled risk and 95% confidence interval (CI) for each meta-analysis.
We included seventeen meta-analyses with 55 comparisons. There was an inverse correlation between breastfeeding and childhood leukaemia (pooled risk = 0.90, 95% CI = 0.81-0.99), neuroblastoma (pooled risk = 0.81, 95% CI = 0.71-0.93), maternal ovarian cancer (pooled risk = 0.76, CI = 0.71-0.81), breast cancer (pooled risk = 0.85, 95% CI = 0.82-0.88), and oesophageal cancer (pooled risk = 0.67, 95% CI = 0.54-0.81) for "ever" vs "never" breastfeeding; and with childhood leukaemia (pooled risk = 0.94, 95% CI = 0.89-0.98), and maternal ovarian cancer (pooled risk = 0.84, 95% CI = 0.78-0.90) and breast cancer (pooled risk = 0.92, 95% CI = 0.89-0.96) for "longest" vs "shortest" breastfeeding duration.
We found evidence that breastfeeding may reduce the risk of maternal breast cancer, ovarian cancers, and childhood leukaemia, suggesting positive implications for influencing women's decision in breastfeeding.
PROSPERO (CRD42021255608).
多项研究和荟萃分析声称母乳喂养与母婴癌症呈负相关。这些结果可能是因果关系，也可能受到共同风险因素的影响。通过进行伞式审查，我们旨在综合母乳喂养与母婴癌症之间的关系。
我们从成立到 2022 年 12 月在 PubMed、Embase、Web of Science、Elsevier ScienceDirect 和 Cochrane Library 数据库中进行了搜索。两位评审员独立使用标准化表格提取数据并评估研究质量。我们考虑了两种类型的母乳喂养比较（“曾经”与“从未”母乳喂养；以及“最长”与“最短”持续时间）。我们为每个荟萃分析估计了汇总风险和 95%置信区间（CI）。
我们纳入了十七项荟萃分析，包含 55 项比较。母乳喂养与儿童白血病（汇总风险=0.90，95%CI=0.81-0.99）、神经母细胞瘤（汇总风险=0.81，95%CI=0.71-0.93）、母亲卵巢癌（汇总风险=0.76，CI=0.71-0.81）、乳腺癌（汇总风险=0.85，95%CI=0.82-0.88）和食道癌（汇总风险=0.67，95%CI=0.54-0.81）呈负相关对于“曾经”与“从未”母乳喂养；以及儿童白血病（汇总风险=0.94，95%CI=0.89-0.98）和母亲卵巢癌（汇总风险=0.84，95%CI=0.78-0.90）和乳腺癌（汇总风险=0.92，95%CI=0.89-0.96）对于“最长”与“最短”母乳喂养时间。
我们有证据表明母乳喂养可能降低母婴乳腺癌、卵巢癌和儿童白血病的风险，这表明对影响女性母乳喂养决策具有积极意义。
PROSPERO（CRD42021255608）。
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