Cheng Pengfei, Yu Jia, Huang Wen, Bai Shunjie, Zhu Xiaofeng, Qi Zhigang, Shao Weihua, Xie Peng
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.
Neurol Sci. 2015 Dec;36(12):2269-75. doi: 10.1007/s10072-015-2349-0. Epub 2015 Aug 12.
Although some studies have reported the associations between specific metal element intake and risk of Parkinson's disease (PD), the associations between specific metal element intake such as iron intake and PD are still conflicted. We aimed to determine whether intake of iron, zinc, and copper increases/decreases the risk of PD. PubMed, Embase, Web of Knowledge, and Google Scholar were searched. We pooled the multivariate-adjusted relative risks (RRs) or odds ratios using random effects. Study quality was evaluated by the Newcastle-Ottawa Scale. Five studies including 126,507 individuals remained for inclusion, pooled RRs of Parkinson's disease for moderate dietary iron intake was 1.08 (95 % CI 0.61-1.93, P = 0.787), and for high dietary iron intake was (1.03, 95 % CI 0.83-1.30, P = 0.766), respectively. The pooled RRs of Parkinson's disease for the highest compared with the lowest dietary iron intake were 1.47 (95 % CI 1.17-1.85, P = 0.001) in western population and in males (RR = 1.43, 95 % CI 1.01-2.01, P = 0.041). The pooled RRs of Parkinson's disease for moderate or high intake of zinc, and copper were not statistically different (P > 0.05). PD increased by 18 % (RR 1.18, 95 % CI 1.02-1.37) for western population by every 10-mg/day increment in iron intake. Higher iron intake appears to be not associated with overall PD risk, but may be associated with risk of PD in western population. Sex may be a factor influencing PD risk for higher iron intake. However, further studies are still needed to confirm the sex-selective effects.
尽管一些研究报告了特定金属元素摄入量与帕金森病（PD）风险之间的关联，但铁摄入量等特定金属元素摄入量与PD之间的关联仍存在矛盾。我们旨在确定铁、锌和铜的摄入量是否会增加/降低PD风险。检索了PubMed、Embase、Web of Knowledge和谷歌学术。我们使用随机效应汇总多变量调整后的相对风险（RRs）或比值比。采用纽卡斯尔-渥太华量表评估研究质量。纳入了五项研究，共126507人，中等饮食铁摄入量患帕金森病的汇总RR为1.08（95%CI 0.61-1.93，P=0.787），高饮食铁摄入量患帕金森病的汇总RR为1.03（95%CI 0.83-1.30，P=0.766）。西方人群和男性中，饮食铁摄入量最高与最低相比，患帕金森病的汇总RR分别为1.47（95%CI 1.17-1.85，P=0.001）和1.43（95%CI 1.01-2.01，P=0.041）。锌和铜的中等或高摄入量患帕金森病的汇总RR无统计学差异（P>0.05）。西方人群铁摄入量每增加10毫克/天，PD风险增加18%（RR 1.18，95%CI 1.02-1.37）。较高的铁摄入量似乎与总体PD风险无关，但可能与西方人群的PD风险有关。性别可能是影响高铁摄入量下PD风险的一个因素。然而，仍需要进一步研究来证实性别选择性效应。
