Wang Yuyi, Yang Guoyan, Gong Juan, Lu Fang, Diao Qingchun, Sun Jin, Zhang Kang, Tian Jinzhou, Liu Jianping
Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Curr Top Med Chem. 2016;16(5):529-36. doi: 10.2174/1568026615666150813143753.
There is no curative treatment for Alzheimer's disease (AD). Ginseng is widely used in the treatment of AD in Asian countries.
To evaluate the effectiveness and safety of ginseng for AD.
We searched seven main databases for randomized clinical trials (RCTs) on ginseng for AD from their inception to December 2014. The Cochrane risk of bias tool was used to assess the methodological quality. We used RevMan 5.2 to synthesize the results.
Four RCTs involving 259 participants were identified for this systematic review. The methodological quality of included studies was not promising. All comparisons were made between combined treatment (ginseng plus conventional treatment) versus conventional treatment. The results of meta-analyses and several individual studies showed that the effectiveness of combined treatment was inconsistent as measured by MMSE, ADAS-cog, ADAS-noncog, and CDR. No studies reported the outcomes of quality of life (QoL). The current data did not report serious adverse events.
This review showed that the effects of ginseng on AD were still inconclusive. The main limitations of the available studies were small sample sizes, poor methodological qualities and no placebo controls. Larger, well-designed studies are needed to test the effect of ginseng on AD in the future.
阿尔茨海默病（AD）尚无治愈性治疗方法。人参在亚洲国家被广泛用于治疗AD。
评估人参治疗AD的有效性和安全性。
我们检索了七个主要数据库，以查找从数据库建立至2014年12月期间关于人参治疗AD的随机临床试验（RCT）。使用Cochrane偏倚风险工具评估方法学质量。我们使用RevMan 5.2对结果进行综合分析。
本系统评价纳入了四项涉及259名参与者的RCT。纳入研究的方法学质量不太理想。所有比较均在联合治疗（人参加常规治疗）与常规治疗之间进行。荟萃分析和几项个体研究的结果表明，以简易精神状态检查表（MMSE）、阿尔茨海默病评估量表认知部分（ADAS-cog）、阿尔茨海默病评估量表非认知部分（ADAS-noncog）和临床痴呆评定量表（CDR）衡量，联合治疗的有效性并不一致。没有研究报告生活质量（QoL）的结果。现有数据未报告严重不良事件。
本综述表明人参对AD的影响仍不明确。现有研究的主要局限性在于样本量小、方法学质量差且无安慰剂对照。未来需要开展更大规模、设计良好的研究来检验人参对AD的作用。
