Department of Otorhinolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China ; Department of Head and Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Int J Endocrinol. 2015;2015:250542. doi: 10.1155/2015/250542. Epub 2015 Jul 26.
The aim of this study was to investigate the possible influence of different genotypes of the lead single nucleotide polymorphisms (SNPs) rs10917468 and rs12045440 in the CAPZB gene on the thyroid function in papillary thyroid carcinoma (PTC) and benign thyroid neoplasm (BN) patients. In the study, a significant association was detected between rs12045440 and serum TSH concentrations in thyroid tumor patients (p = 0.001). After the adjustment of relevant covariates, the difference between the mean serum TSH levels in different genotypes of rs12045440 was still significant in the BN group (p = 0.003) but was not significant in the PTC cases (p = 0.115). No significant association of rs10917468 with TSH levels was found. The SNP rs12045440 was associated with the serum TSH concentrations in Chinese thyroid tumor patients, especially in benign thyroid tumor cases.
本研究旨在探讨 CAPZB 基因中铅单核苷酸多态性（SNP）rs10917468 和 rs12045440 的不同基因型对甲状腺乳头状癌（PTC）和良性甲状腺肿瘤（BN）患者甲状腺功能的可能影响。在研究中，rs12045440 与甲状腺肿瘤患者的血清 TSH 浓度之间存在显著关联（p = 0.001）。在调整了相关协变量后，rs12045440 不同基因型之间的平均血清 TSH 水平差异在 BN 组中仍然显著（p = 0.003），但在 PTC 病例中不显著（p = 0.115）。未发现 rs10917468 与 TSH 水平之间存在显著关联。SNP rs12045440 与中国甲状腺肿瘤患者的血清 TSH 浓度相关，尤其是在良性甲状腺肿瘤病例中。
