Zhang Pingping, Li Qiuxia, Wei Qiujing, Liao Zetao, Lin Zhiming, Fang Linkai, Gu Jieruo
Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China.
Biomed Res Int. 2015;2015:543806. doi: 10.1155/2015/543806. Epub 2015 Jul 26.
To assess the serum vitamin D and ICTP levels in patients with ankylosing spondylitis (AS) and investigate their relationship with disease activity and bone mineral density (BMD).
150 patients and 168 controls were included. Serum 25(OH)D, ICTP, C-reaction protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and Hip BMD were assessed in patients. 25(OH)D and ICTP were detected in controls.
The serum 25(OH)D in AS was 57.92 ± 24.42 nmol/L, significantly lower than controls (91.24 ± 42.02 nmol/L). Serum ICTP in AS was 5.72 ± 3.88 ug/L, significantly higher than controls (3.69 ± 1.26 ug/L). ICTP level was higher in men than in women patients (6.07 ± 4.05 versus 3.84 ± 1.96 ug/L, P ≤ 0.01); it was also higher in JAS than in AAS (9.52 ± 3.79 versus 5.27 ± 3.65 ug/L, P ≤ 0.01). Furthermore, 25(OH)D was negatively correlated with ICTP. Low 25(OH)D and high ICTP were one of the reasons of AS patients' low hip BMD. Besides, a significant relationship was found between serum ICTP and CRP.
There was a high incidence of vitamin D inadequacy in AS. Serum ICTP level was elevated in AS, especially in JAS and male patients. 25(OH)D and ICTP seem to be valuable markers to detect bone loss in AS.
评估强直性脊柱炎（AS）患者血清维生素D和血清Ⅰ型胶原羧基末端肽（ICTP）水平，并探讨其与疾病活动度及骨密度（BMD）的关系。
纳入150例患者和168例对照。对患者评估血清25（OH）D、ICTP、C反应蛋白（CRP）、巴斯强直性脊柱炎疾病活动指数（BASDAI）、巴斯强直性脊柱炎功能指数（BASFI）及髋部骨密度。对对照检测25（OH）D和ICTP。
AS患者血清25（OH）D为57.92±24.42 nmol/L，显著低于对照（91.24±42.02 nmol/L）。AS患者血清ICTP为5.72±3.88 μg/L，显著高于对照（3.69±1.26 μg/L）。男性患者ICTP水平高于女性患者（6.07±4.05对3.84±1.96 μg/L，P≤0.01）；幼年型强直性脊柱炎（JAS）患者ICTP水平高于成年型强直性脊柱炎（AAS）患者（9.52±3.79对5.27±3.65 μg/L，P≤0.01）。此外，25（OH）D与ICTP呈负相关。低水平的25（OH）D和高水平的ICTP是AS患者髋部骨密度降低的原因之一。此外，血清ICTP与CRP之间存在显著相关性。
AS患者维生素D缺乏发生率较高。AS患者血清ICTP水平升高，尤其是JAS患者和男性患者。25（OH）D和ICTP似乎是检测AS患者骨质流失的有价值指标。
