Liu Supin, Wang Wenlong, Yin Linlin, Zhu Yitang
Supin Liu, Blood Collection Centre, The Centre Hospital of Cangzhou, Cangzhou City, Hebei Province, China.
Wenlong Wang, Department of Clinical Laboratory, The Centre Hospital of Cangzhou, Cangzhou City, Hebei Province, China.
Pak J Med Sci. 2018 Jan-Feb;34(1):159-163. doi: 10.12669/pjms.341.14135.
To investigate the relationship between serum level of Apelin-13 and bone mineral density (BMD) as well as other parameters, and determine the influence of Apelin-13 on osteoporosis in patients with Type-2 diabetes mellitus.
Seventy-six patients with Type-2 diabetes mellitus were recruited from Department of Endocrinology of our hospital between January 2013 and July2017. The clinical data, including age, gender, height, weight, body mass index (BMI) and disease duration were recorded for all patients. Blood sample was collected for measurement of Apelin-13, Procollagen type-I N propeptide (PINP) and Cross-linked carboxy terminal telopeptide of type-I collagen (ICTP), and BMD was tested with a dual-energy X-ray absorptiometry scanner.
The patients were divided into three groups, in which 19 patients were assigned in osteoporosis group, 25 in osteopenia group and 32 in normal group. The level of Apelin-13 in osteoporosis group was significantly lower than that in osteopenia and normal groups (p<0.05), and the value in osteopenia group was significant lower than that in normal group (p<0.05). Correlation analysis showed in the included patients the level of Apelin-13 was positively correlated to the value of BMD and PINP (p<0.05), but negatively correlated to age and ICTP (p<0.05).
In conclusion, this study demonstrated that there was a close relationship among Apelin-13, BMD, ICTP and PINP, and Apelin-13 plays an important role in the occurrence of osteoporosis in patients with Type-2 diabetes mellitus.
探讨血清Apelin-13水平与骨密度（BMD）及其他参数之间的关系，并确定Apelin-13对2型糖尿病患者骨质疏松症的影响。
选取2013年1月至2017年7月我院内分泌科收治的76例2型糖尿病患者。记录所有患者的临床资料，包括年龄、性别、身高、体重、体重指数（BMI）和病程。采集血样检测Apelin-13、I型前胶原N端前肽（PINP）和I型胶原交联羧基末端肽（ICTP），并用双能X线吸收仪检测骨密度。
将患者分为三组，其中骨质疏松组19例，骨量减少组25例，正常组32例。骨质疏松组Apelin-13水平显著低于骨量减少组和正常组（p<0.05），骨量减少组的值显著低于正常组（p<0.05）。相关性分析显示，纳入患者中Apelin-13水平与骨密度和PINP值呈正相关（p<0.05），但与年龄和ICTP呈负相关（p<0.05）。
本研究表明，Apelin-13、骨密度、ICTP和PINP之间存在密切关系，Apelin-13在2型糖尿病患者骨质疏松症的发生中起重要作用。
