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动脉内血栓切除术:侵入性治疗是否比单纯静脉溶栓能带来更好的治疗效果?

Intra-arterial thrombectomy: does invasive treatment lead to better outcomes than intravenous thrombolysis alone?

作者信息

Cherian Laurel, Cutting Shawna, Song Sarah

机构信息

Section of Cerebrovascular Disease, Department of Neurology, Rush University Medical Center, 1725 W. Harrison Street, Suite 1121, Chicago, IL, 60612, USA,

出版信息

Curr Cardiol Rep. 2015 Oct;17(10):82. doi: 10.1007/s11886-015-0639-z.

DOI:10.1007/s11886-015-0639-z
PMID:26277366
Abstract

Intravenous thrombolysis is considered to be standard of care for acute ischemic stroke patients arriving within 3-4.5 h of stroke symptom onset. Recently, endovascular therapies have been proposed to extend and enhance stroke outcomes by targeting large vessel occlusions. Different radiologic methods, time windows, and treatment tools have delineated differences between trials. Overall, intravenous thrombolysis remains the treatment of choice for all acute ischemic stroke patients, with a small subset benefiting from additional endovascular therapy. Endovascular therapy remains a viable singular option for patients with large vessel occlusion unable to receive thrombolysis.

摘要

静脉溶栓被认为是卒中症状发作后3 - 4.5小时内就诊的急性缺血性卒中患者的标准治疗方法。最近,血管内治疗已被提出,旨在通过针对大血管闭塞来扩大和改善卒中治疗效果。不同的影像学方法、时间窗和治疗工具在各试验之间划出了差异。总体而言,静脉溶栓仍然是所有急性缺血性卒中患者的首选治疗方法,一小部分患者可从额外的血管内治疗中获益。血管内治疗对于无法接受溶栓的大血管闭塞患者仍然是一种可行的单一治疗选择。

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本文引用的文献

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Thrombectomy within 8 hours after symptom onset in ischemic stroke.发病 8 小时内进行缺血性脑卒中取栓治疗。
N Engl J Med. 2015 Jun 11;372(24):2296-306. doi: 10.1056/NEJMoa1503780. Epub 2015 Apr 17.
2
Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.血管内溶栓联合支架取栓与单纯静脉溶栓治疗脑卒中的比较。
N Engl J Med. 2015 Jun 11;372(24):2285-95. doi: 10.1056/NEJMoa1415061. Epub 2015 Apr 17.
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Effect of extended CT perfusion acquisition time on ischemic core and penumbra volume estimation in patients with acute ischemic stroke due to a large vessel occlusion.
延长CT灌注采集时间对大血管闭塞所致急性缺血性脑卒中患者缺血核心区和半暗带体积估计的影响。
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Relative CBV ratio on perfusion-weighted MRI indicates the probability of early recanalization after IV t-PA administration for acute ischemic stroke.灌注加权磁共振成像上的相对脑血容量比值表明了急性缺血性卒中静脉注射组织型纤溶酶原激活剂(IV t-PA)后早期再通的可能性。
J Neurointerv Surg. 2016 Mar;8(3):235-9. doi: 10.1136/neurintsurg-2014-011501. Epub 2015 Jan 12.
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A randomized trial of intraarterial treatment for acute ischemic stroke.急性缺血性脑卒中的动脉内治疗随机试验。
N Engl J Med. 2015 Jan 1;372(1):11-20. doi: 10.1056/NEJMoa1411587. Epub 2014 Dec 17.
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