von Hahn Thomas, Ciesek Sandra
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Germany; Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany.
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Germany.
Curr Opin Virol. 2015 Oct;14:47-9. doi: 10.1016/j.coviro.2015.07.012. Epub 2015 Aug 13.
Viruses are obligate intracellular parasites. All stages of their replication cycle depend on support by host-encoded factors. However, sequence variation also exists in host factors mostly in the form of single nucleotide polymorphisms (SNPs). Several coding and non-coding genetic variants in the PPIA gene encoding for CypA have been described, but there is only limited information about their influence on the course of viral infection. This paper reviews PPIA polymorphisms and what is known about their impact on the replication cycle and course of disease for different viral infections.
病毒是专性细胞内寄生虫。其复制周期的所有阶段都依赖宿主编码因子的支持。然而,宿主因子中也存在序列变异,大多以单核苷酸多态性(SNP)的形式存在。编码环孢素A(CypA)的肽基脯氨酰异构酶A(PPIA)基因中有几种编码和非编码基因变体已被描述,但关于它们对病毒感染进程影响的信息有限。本文综述了PPIA基因多态性及其对不同病毒感染的复制周期和病程影响的已知情况。