Pandolfi Anna
Department of Civil and Environmental Engineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milano, 20133 Italy.
Eye Vis (Lond). 2020 Jan 7;7:2. doi: 10.1186/s40662-019-0166-x. eCollection 2020.
Biomechanics introduces numerous technologies to support clinical practice in ophthalmology, with the goal of improving surgical outcomes and to develop new advanced technologies with minimum impact on clinical training. Unfortunately, a few misconceptions on the way that computational methods should be applied to living tissues contributes to a lack of confidence towards computer-based approaches.
Corneal biomechanics relies on sound theories of mechanics, including concepts of equilibrium, geometrical measurements, and complex material behaviors. The peculiarities of biological tissues require the consideration of multi-physics, typical of the eye environment, and to adopt customized geometrical models constructed on the basis of advanced optical imaging and in-vivo testing.
Patient-specific models are able to predict the outcomes of refractive surgery and to exploit the results of in-vivo test to characterize the material properties of the corneal tissue.
Corneal biomechanics can become an important support to clinical practice, provided that methods are based on the actual multi-physics and use customized geometrical and mechanical models.
生物力学引入了众多技术以支持眼科临床实践，目的是改善手术效果并开发对临床培训影响最小的新型先进技术。不幸的是，对于如何将计算方法应用于活体组织存在一些误解，这导致人们对基于计算机的方法缺乏信心。
角膜生物力学依赖于坚实的力学理论，包括平衡概念、几何测量和复杂材料行为。生物组织的特性需要考虑眼部环境典型的多物理特性，并采用基于先进光学成像和体内测试构建的定制几何模型。
针对患者的模型能够预测屈光手术的结果，并利用体内测试结果来表征角膜组织的材料特性。
只要方法基于实际的多物理特性并使用定制的几何和力学模型，角膜生物力学就能成为临床实践的重要支持。
