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[47例蕈样肉芽肿患者的光化学疗法结果]

[Results of photochemotherapy in a series of 47 patients with mycosis fungoides].

作者信息

Piccinno R, Caccialanza M, Mainardi L

出版信息

G Ital Dermatol Venereol. 1989 Jul-Aug;124(7-8):369-73.

PMID:2628282
Abstract

Oral photochemotherapy has been employed in the treatment of mycosis fungoides for more than 13 years. The Authors report their 9 year experience in a series of 47 patients affected by mycosis fungoides and treated by means of PUVA-therapy. All the patients were staged according to TNM system. 81.5% of 38 cases in the I stage of the disease obtained a complete remission, as did 50% of 6 cases in the II stage and one patient out of 3 in the III stage. Photochemotherapy seems to give satisfactory results mainly in the first stages of the disease. In fact, 45% of the patients who had obtained complete remission ot the end of the treatment were still free from disease after 5 years. Photochemotherapy, which in this series has not shown any important side effect, is a safe non-aggressive therapeutic choice in the management of the first stages of mycosis fungoides.

摘要

口服光化学疗法已用于蕈样肉芽肿的治疗超过13年。作者报告了他们对47例蕈样肉芽肿患者采用补骨脂素紫外线A疗法(PUVA疗法)进行治疗的9年经验。所有患者均根据TNM系统进行分期。疾病I期的38例患者中,81.5%获得完全缓解;II期的6例患者中,50%获得完全缓解;III期的3例患者中有1例获得完全缓解。光化学疗法似乎主要在疾病的早期阶段能取得令人满意的效果。事实上,治疗结束时获得完全缓解的患者中有45%在5年后仍无疾病复发。在本系列研究中,光化学疗法未显示出任何严重的副作用,是治疗蕈样肉芽肿早期阶段一种安全、非侵袭性的治疗选择。

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