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蕈样肉芽肿肿瘤前期的光化学疗法(补骨脂素加长波紫外线疗法,PUVA):来自斯堪的纳维亚蕈样肉芽肿研究组的报告

Photochemotherapy (PUVA) in the pretumour stage of mycosis fungoides: a report from the Scandinavian Mycosis Fungoides Study Group.

作者信息

Molin L, Thomsen K, Volden G, Groth O

出版信息

Acta Derm Venereol. 1981;61(1):47-51.

PMID:6164214
Abstract

Fifty-one patients with mycosis fungoides of pretumour stage were treated with oral 8-MOP and UVA photochemotherapy (PUVA). Complete remission was induced within 2--3 months in 58% of the cases. Twenty-seven patients are still in remission on maintenance therapy 9--53 months after starting treatment. In 9 cases PUVA treatment was stopped due to therapeutic failure and in another 15 cases due to various side effects. Maintenance therapy was given weekly, monthly, or at even longer intervals. Maintenance at long intervals seems preferable.

摘要

51例蕈样肉芽肿前期患者接受了口服8-甲氧基补骨脂素(8-MOP)和长波紫外线光化学疗法(PUVA)治疗。58%的病例在2至3个月内诱导达到完全缓解。27例患者在开始治疗9至53个月后维持治疗仍处于缓解状态。9例因治疗失败停止PUVA治疗,另外15例因各种副作用停止治疗。维持治疗每周、每月或间隔更长时间进行一次。间隔较长时间进行维持治疗似乎更为可取。

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