Klengel Torsten, Dias Brian G, Ressler Kerry J
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
Department of Psychiatry and Behavioral Sciences and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Neuropsychopharmacology. 2016 Jan;41(1):219-31. doi: 10.1038/npp.2015.249. Epub 2015 Aug 18.
Trajectories toward risk or resilience in psychiatric disorders are influenced by acquired and inherited factors. More recently, evidence from rodent studies suggest that acquired risk factors can be transmitted through non-genomic, epigenetic mechanisms to subsequent generations, potentially contributing to a cycle of disease and disease risk. Here, we review examples of transmission of environmental factors across generations and illustrate the difference between behavioral transmission and epigenetic inheritance. We highlight essential definitions of intergenerational and transgenerational transmission of disease risk with corresponding examples. We then explore how these phenomena may influence our understanding of psychiatric disorders leading toward new prevention and therapeutic approaches.
精神疾病中走向风险或恢复力的轨迹受到后天因素和遗传因素的影响。最近，来自啮齿动物研究的证据表明，后天风险因素可以通过非基因组的表观遗传机制传递给后代，这可能导致疾病和疾病风险的循环。在这里，我们回顾了环境因素跨代传递的例子，并阐述了行为传递和表观遗传继承之间的区别。我们强调了疾病风险代际传递和跨代传递的基本定义，并给出了相应的例子。然后，我们探讨这些现象如何影响我们对精神疾病的理解，从而带来新的预防和治疗方法。
